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Titolo:
DENDRITIC CELLS - FROM IGNORED CELLS TO MAJOR PLAYERS IN T-CELL-MEDIATED IMMUNITY
Autore:
SCHULER G; THURNER B; ROMANI N;
Indirizzi:
UNIV ERLANGEN NURNBERG,DERMATOL KLIN,DEPT DERMATOL,HARTMANNSTR 14 D-91054 ERLANGEN GERMANY INNSBRUCK UNIV,DEPT DERMATOL A-6020 INNSBRUCK AUSTRIA
Titolo Testata:
International archives of allergy and immunology
fascicolo: 4, volume: 112, anno: 1997,
pagine: 317 - 322
SICI:
1018-2438(1997)112:4<317:DC-FIC>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL LANGERHANS CELLS; ANTIGEN PROCESSING CAPACITY; COLONY-STIMULATING FACTOR; CLASS-II; DOWN-REGULATION; CULTURE; BLOOD; IDENTIFICATION; COMPARTMENT; MATURATION;
Keywords:
DENDRITIC CELLS; ANTIGEN-PRESENTING CELLS; T-CELL-MEDIATED IMMUNITY; VACCINATION; TOLERANCE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
G. Schuler et al., "DENDRITIC CELLS - FROM IGNORED CELLS TO MAJOR PLAYERS IN T-CELL-MEDIATED IMMUNITY", International archives of allergy and immunology, 112(4), 1997, pp. 317-322

Abstract

Dendritic cells form a system of leukocytes specialized to stimulate resting T cells in vivo. Dendritic cells are crucial for the initiation of primary immune responses of both helper and cytotoxic T lymphocytes, and thus act as 'nature's adjuvant'. The manifold specializations underlying this in vivo immunostimulatory function are becoming increasingly clear. Methods have been developed to generate large numbers ofdendritic cells from hematopoietic precursors in vitro. These techniques now allow molecular studies as well as the use of antigen-charged dendritic cells to vaccinate patients against tamers (e.g. B-cell lymphoma or melanoma) and infection (e.g. HIV-1). Recent data suggest thatbesides the classical immunostimulatory dendritic cells which belong to the myeloid lineage, there exist regulatory dendritic cells relatedto the lymphoid lineage. These lymphoid-derived dendritic cells whichat least in part express Fas-ligand appear to be involved in the induction of central as well as peripheral tolerance, and in the future might allow a novel approach to induce tolerance in transplantation, autoimmunity, and allergy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 05:16:42