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Titolo:
CHANGES IN ANTIOXIDANT ENZYMES ACTIVITIES, AGGREGABILITY AND MALONYLDIALDEHYDE CONCENTRATION IN BLOOD-PLATELETS FROM PATIENTS WITH CORONARYHEART-DISEASE
Autore:
BUCZYNSKI A; WACHOWICZ B; KEDZIORAKORNATOWSKA K; TKACZEWSKI W; KEDZIORA J;
Indirizzi:
MIL MED ACAD,INST FUNDAMENTAL SCI,DEPT PHYSIOL PL-90647 LODZ POLAND UNIV LODZ,DEPT BIOCHEM PL-90131 LODZ POLAND MIL MED ACAD,DEPT INTERNAL MED PL-90647 LODZ POLAND
Titolo Testata:
Atherosclerosis
fascicolo: 2, volume: 100, anno: 1993,
pagine: 223 - 228
SICI:
0021-9150(1993)100:2<223:CIAEAA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREE-RADICALS; ASSAY;
Keywords:
CORONARY HEART DISEASE; BLOOD PLATELETS; ANTIOXIDANT SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
A. Buczynski et al., "CHANGES IN ANTIOXIDANT ENZYMES ACTIVITIES, AGGREGABILITY AND MALONYLDIALDEHYDE CONCENTRATION IN BLOOD-PLATELETS FROM PATIENTS WITH CORONARYHEART-DISEASE", Atherosclerosis, 100(2), 1993, pp. 223-228

Abstract

In 41 patients with coronary heart disease (CHD) the concentrations of total blood platelet malonyldialdehyde (MDA: 2.11 +/- 0.25 nmol/109 platelets) and MDA corresponding to thromboxane A2 (TXA2 0.84 +/- 0.13nmol/109 platelets) were increased in comparison with values in bloodplatelets of healthy subjects (1.19 +/- 0.09 and 0.71 +/- 0.05 nmol/10(9) platelets), respectively. The increased aggregability with ADP and thrombin of patient platelets was also observed. In relation to the blood platelets of healthy subjects, the antioxidant enzymes activities of patient blood platelets were significantly (P < 0.001) decreased. Platelet glutathione peroxidase (GSH-Px) activity of the patients (11.3 +/- 0.85 U/g protein) was significantly lower than controls (18.3 +/- 1.12 U/g protein). In patients with CHD the activities of the otherantioxidative platelet enzymes: catalase (Cat, 7.37 +/- 1.38 U/g protein) and superoxide dismutase (SOD, 1529.4 +/- 167 U/g protein) were also significantly decreased in comparison with values for healthy subjects (Cat: 9.06 +/- 1.30 U/g protein and SOD: 1987 +/- 230 U/g protein, respectively). It is suggested that antioxidative defense in blood platelets may affect the haemostatic processes and lipid peroxidation in patients with CHD.

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Documento generato il 01/04/20 alle ore 10:05:43