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Titolo:
HALOPERIDOL RESPONSE AND PLASMA-CATECHOLAMINES AND THEIR METABOLITES
Autore:
GREEN AI; ALAM MY; BOSHES RA; WATERNAUX C; PAPPALARDO KM; FITZGIBBON ME; TSUANG MT; SCHILDKRAUT JJ;
Indirizzi:
74 FENWOOD RD BOSTON MA 02115 MASSACHUSETTS MENTAL HLTH CTR,COMMONWEALTH RES CTR BOSTON MA 02115 MASSACHUSETTS MENTAL HLTH CTR,NEUROPSYCHOPHARMACOL PSYCHIAT CHEM LAB BOSTON MA 02115 METROPOLITAN STATE HOSP BOSTON MA 00000 HARVARD UNIV,SCH MED,DEPT PSYCHIAT BOSTON MA 02115 NEW ENGLAND DEACONESS HOSP BOSTON MA 02215 VET ADM MED CTR BROCKTON MA 02401 VET ADM MED CTR W ROXBURY BOSTON MA 02132
Titolo Testata:
Schizophrenia research
fascicolo: 1, volume: 10, anno: 1993,
pagine: 33 - 37
SICI:
0920-9964(1993)10:1<33:HRAPAT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; HOMOVANILLIC-ACID; ELECTROCHEMICAL DETECTION; SCHIZOPHRENIC-PATIENTS; DOPAMINE; PREDICTOR; PSYCHOSIS;
Keywords:
HALOPERIDOL RESPONSE; CATECHOLAMINE; HOMOVANILLIC ACID; 3-METHOXY-4-HYDROXYPHENYLGLYCOL; (SCHIZOPHRENIA);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
A.I. Green et al., "HALOPERIDOL RESPONSE AND PLASMA-CATECHOLAMINES AND THEIR METABOLITES", Schizophrenia research, 10(1), 1993, pp. 33-37

Abstract

Eleven acutely psychotic patients with schizophrenia or schizoaffective disorder underwent a 5-7 day drug-washout period (with lorazepam allowed) prior to participating in a 6-week controlled dose haloperidol trial. Patients were evaluated longitudinally with clinical ratings and with plasma measures of the catecholamines dopamine (pDA) and norepinephrine (pNE) and their metabolites, homovanillic acid (pHVA) and 3-methoxy-4-hydroxyphenylglycol (pMHPG). All patients exhibited clinical improvement with haloperidol; the decrease in their Brief Psychiatric Rating Scale (BPRS) scores ranged from 32 to 89%. Measures of pHVA increased within the first week of treatment and returned to baseline by week 5. The pattern of change of pDA resembled that of pHVA. The pattern of change of pNE and pMHPG revealed a decrease over the course of treatment. The early increase and the subsequent decrease in pHVA were strongly correlated with improvement in positive symptoms on the BPRS. These data arc consistent with previous reports on the change in pHVAand pMHPG during clinical response to haloperidol. The data on changeof pDA and pNE further describe the nature of the biochemical response to this drug.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:29:49