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Titolo:
RESISTANCE OF MHC CLASS-I-DEFICIENT MICE TO EXPERIMENTAL SYSTEMIC LUPUS-ERYTHEMATOSUS
Autore:
MOZES E; KOHN LD; HAKIM F; SINGER DS;
Indirizzi:
NCI,EXPTL IMMUNOL BRANCH BETHESDA MD 20892 NCI,EXPTL IMMUNOL BRANCH BETHESDA MD 20892 NIDDKD,BIOCHEM & METAB LAB BETHESDA MD 20892
Titolo Testata:
Science
fascicolo: 5117, volume: 261, anno: 1993,
pagine: 91 - 93
SICI:
0036-8075(1993)261:5117<91:ROMCMT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELLS; INDUCTION; IDIOTYPE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
E. Mozes et al., "RESISTANCE OF MHC CLASS-I-DEFICIENT MICE TO EXPERIMENTAL SYSTEMIC LUPUS-ERYTHEMATOSUS", Science, 261(5117), 1993, pp. 91-93

Abstract

Experimental systemic lupus erythematosus (SLE) can be induced in mice by immunization with a human monoclonal antibody to DNA that bears acommon idiotype (16/6Id). These mice generate antibodies to 16/6Id, antibodies to DNA, and antibodies directed against nuclear antigens. Subsequently, manifestations of SLE develop, including leukopenia, proteinuria, and immune complex deposits in the kidney. In contrast, after immunization with 16/6Id, mice lacking major histocompatibility complex (MHC) class I molecules generated antibodies to 16/6Id but did not generate antibodies to DNA or to nuclear antigen. Furthermore, they didnot develop any of the above clinical manifestations. These results reveal an unexpected function of MHC class I in the induction of autoimmune SLE.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 19:47:50