Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
RENAL TOXICITY OF ARISTOLOCHIC ACID IN RATS AS AN EXAMPLE OF NEPHROTOXICITY TESTING IN ROUTINE TOXICOLOGY
Autore:
MENGS U; STOTZEM CD;
Indirizzi:
MADAUS AG,TOXICOL & EXPTL PATHOL,OSTMERHEIMERSTR 198 W-5000 COLOGNE 91 GERMANY
Titolo Testata:
Archives of toxicology
fascicolo: 5, volume: 67, anno: 1993,
pagine: 307 - 311
SICI:
0340-5761(1993)67:5<307:RTOAAI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUTAGENICITY; DYSFUNCTION; INVITRO; ENZYMES;
Keywords:
ARISTOLOCHIC ACID; NEPHROTOXICITY; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
U. Mengs e C.D. Stotzem, "RENAL TOXICITY OF ARISTOLOCHIC ACID IN RATS AS AN EXAMPLE OF NEPHROTOXICITY TESTING IN ROUTINE TOXICOLOGY", Archives of toxicology, 67(5), 1993, pp. 307-311

Abstract

The nephrotoxic action of aristolochic acid (AA) was investigated in female Wistar rats given single doses of 10, 50 or 100 mg/kg by gastric tube. Renal lesions developed within 3 days, the effect being dose-dependent. Histologically, there was evidence of necrosis of the epithelium of the renal tubules, and functionally, there were rises in plasma creatinine and urea together with increases in urinary glucose, protein, N-acetyl-beta-glucosaminidase, gammaglutamyl transferase and malate dehydrogenase. Taking AA as an example, the aim of the present study was to consider the suitability of this model, based on a combination of histology and laboratory investigations, as a short-term test forthe detection of nephrotoxic agents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 07:01:18