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Titolo:
CEREBROSPINAL-FLUID LEVELS OF HOMOVANILLIC-ACID AND 5-HYDROXYINDOLEACETIC ACID IN AUTISM
Autore:
NARAYAN M; SRINATH S; ANDERSON GM; MEUNDI DB;
Indirizzi:
YALE UNIV,SCH MED,DEPT PSYCHIAT,POB 3333 NEW HAVEN CT 06510 NATL INST MENTAL HLTH & NEUROSCI BANGALORE 560029 KARNATAKA INDIA VANI VILAS CHILDRENS HOSP,DEPT PEDIAT BANGALORE INDIA YALE UNIV,SCH MED,CTR CHILD STUDY NEW HAVEN CT 06510
Titolo Testata:
Biological psychiatry
fascicolo: 8-9, volume: 33, anno: 1993,
pagine: 630 - 635
SICI:
0006-3223(1993)33:8-9<630:CLOHA5>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERVASIVE DEVELOPMENTAL DISORDERS; CHILDREN; METABOLITES; MONOAMINES; CHILDHOOD;
Keywords:
CEREBROSPINAL FLUID (CSF); AUTISM; 5-HYDROXYINDOLEACETIC ACID (5HIAA); HOMOVANILLIC ACID (HVA);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
M. Narayan et al., "CEREBROSPINAL-FLUID LEVELS OF HOMOVANILLIC-ACID AND 5-HYDROXYINDOLEACETIC ACID IN AUTISM", Biological psychiatry, 33(8-9), 1993, pp. 630-635

Abstract

Cerebrospinal fluid (CSF) concentrations of the serotonin and dopamine metabolites, 5-hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA), respectively, were measured in a group of 17 children with Autistic Disorder (DSM-III-R). The group means observed for 5HIAA (135 +/- 91 nmol/L) and HVA (502 +/- 324 nmol/L) in the autistic children were not significantly different from those seen in the control group of15 nonneurologically impaired children (5HIAA, 122 +/- 120 nmol/L; HVA 401 +/- 378 nmol/L). These data suggest that consistent, marked alterations in central serotonin and dopamine turnover are not present in the autistic subjects studied. Although studies to date have found little or no alteration in CSF 5-HIAA in autism, the various reports of CSF HVA are not entirely congruent. Although this study is consistent with most previous studies in not finding a group difference in CSF HVA, the possibility of increased CSF HVA in autism cannot be ruled out.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/02/20 alle ore 17:18:20