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Titolo:
AMPLIFICATION OF THE C-ERBB-2 ONCOGENE IN BREAST-CANCER AND ITS RELATIONSHIP TO ESTROGEN AND PROGESTERONE RECEPTORS
Autore:
TODD DM; MILLER JM; RUBIN AD; DEBARI VA;
Indirizzi:
GEN CARE BIOMED RES CORP,271 SHEFFIELD ST MOUNTAINSIDE NJ 07092
Titolo Testata:
Diagnostic oncology
fascicolo: 6, volume: 2, anno: 1992,
pagine: 313 - 317
SICI:
1013-8129(1992)2:6<313:AOTCOI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Keywords:
ONCOGENES; C-ERB-2; ESTROGEN RECEPTORS; PROGESTERONE RECEPTORS; BREAST CANCER; SLOT BLOT ANALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
D.M. Todd et al., "AMPLIFICATION OF THE C-ERBB-2 ONCOGENE IN BREAST-CANCER AND ITS RELATIONSHIP TO ESTROGEN AND PROGESTERONE RECEPTORS", Diagnostic oncology, 2(6), 1992, pp. 313-317

Abstract

The objective of this study was to determine if a relationship existsbetween amplification of the c-erbB-2 oncogene and estrogen and progesterone receptor (ER and PgR, respectively) status in a large group ofunselected breast cancer (BC) patients. Tumors (1,532) submitted to our laboratory for analysis of ER and PgR levels were also subjected toa DNA amplification assay for the oncogene c-erbB-2. For ER, 1,047 of1,532 tumors were positive (68.3%) and for PgR, 845 of 1,532 tumors were positive (55.2%). Of those tumors evaluated for c-erbB-2 amplification, 14.2% were positive (217/1,532). Correlation of ER and PgR with c-erbB-2) indicated a highly significant inverse correlation (p < 0.0001) for receptor and oncogene positivity; ER-negative tumors were twice as likely to be c-erbB-2 positive (115 c-erbB-2 positive of 485 ER negative: 23.7%) than ER-positive tumors (102 c-crbB-2 positive of 1,047 ER posit ve: 9.7%). For PgR-positive tumors, 85 of 845 (10.1%) were c-erbB-2 positive whereas PgR-negative tumors demonstrated c-erbB-2 positivity in 132 of 687 specimens (19.2%). Again, receptor-negative tumors were twice as likely to show oncogene amplification. Although we caution against the inference of a direct cause and effect relationshipbetween these parameters, we suggest that these laboratory findings mirror clinical experiences which suggest improved prognosis in ER- andPgR-positive BC patients and a poorer outcome in more aggressive disease which demonstrates amplification of c-erbB-2.

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Documento generato il 26/09/20 alle ore 11:11:51