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Titolo:
GLUTAMATE STIMULATES GLUCAGON-SECRETION VIA AN EXCITATORY AMINO-ACID RECEPTOR OF THE AMPA SUBTYPE IN RAT PANCREAS
Autore:
BERTRAND G; GROSS R; PUECH R; LOUBATIERESMARIANI MM; BOCKAERT J;
Indirizzi:
CTR PHARMACOL ENDOCRINOL,CNRS,INSERM,RUE CARDONILLE F-34094 MONTPELLIER 5 FRANCE FAC PHARM MONTPELLIER,INST BIOL,PHARMACOL LAB F-34060 MONTPELLIER FRANCE
Titolo Testata:
European journal of pharmacology
fascicolo: 1, volume: 237, anno: 1993,
pagine: 45 - 50
SICI:
0014-2999(1993)237:1<45:GSGVAE>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIPPOCAMPAL-NEURONS; INSULIN-SECRETION; MYENTERIC PLEXUS; NERVOUS-SYSTEM; MOUSE; ASPARTATE; CHANNELS; RELEASE; KAINATE; ANTAGONISTS;
Keywords:
GLUTAMATE; AMPA RECEPTORS; GLUCAGON RELEASE; PANCREAS (RAT);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
G. Bertrand et al., "GLUTAMATE STIMULATES GLUCAGON-SECRETION VIA AN EXCITATORY AMINO-ACID RECEPTOR OF THE AMPA SUBTYPE IN RAT PANCREAS", European journal of pharmacology, 237(1), 1993, pp. 45-50

Abstract

The effect of L-glutamate was studied on glucagon secretion from rat isolated pancreas perfused with 2.8 mM glucose. L-Glutamate (3.10(-5)-10(-4) M) induced an immediate, transient and concentration-dependent glucagon release. The three non-N-methyl-D-aspartate (NMDA) receptor agonists, kainate (3.10(-5)-3.10(-3) M), lpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) (3.10(-5)-10(-4) M) and quisqualate (3.10(-6)-10(-5) M), all elicited a peak-shaped glucagon response. Compared to glutamate, AMPA and quisqualate exhibited a similar efficacy, whereas kainate caused a 4-fold higher maximal glucagon response. In contrast, NMDA (10(-3) M) was ineffective. The selective antagonist of non-NMDA receptors, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX; 5.10(-5) M), totally prevented the glucagon response to 10(-4) M glutamate (IC50 congruent-to 0.8 +/- 0.3 10(-6) M) and 3.10(-4) M kainate. Furthermore, quisqualate at a maximal effective concentration (3.10(-4) M) inhibited the response to kainate (10(-3) M). This study showed that L-glutamate stimulates glucagon release in rat pancreas by activating a receptor of the AMPA subtype.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 11:53:51