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Titolo:
HEART-RATE AND HEART-RATE-VARIABILITY, A PHARMACOLOGICAL TARGET
Autore:
SWYNGHEDAUW B; JASSON S; CHEVALIER B; CLAIRAMBAULT J; HARDOUIN S; HEYMES C; MANGIN L; MANSIER P; MEDIGUE C; MOALIC JM; THIBAULT N; CARRE F;
Indirizzi:
HOP LARIBOISIERE,INSERM,U127,IFR CIRCULAT,41 BD LA CHAPELLE F-75475 PARIS 10 FRANCE INRIA,UNITE ROCQUENCOURT LE CHESNAY FRANCE UNIV RENNES,DEPT PHYSIOL RENNES FRANCE IRIS COURBEVOIE FRANCE
Titolo Testata:
Cardiovascular drugs and therapy
fascicolo: 6, volume: 10, anno: 1997,
pagine: 677 - 685
SICI:
0920-3206(1997)10:6<677:HAHAPT>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIAC-HYPERTROPHY; TRANSGENIC MICE; MYOCARDIAL-INFARCTION; AUTONOMIC REGULATION; NONLINEAR DYNAMICS; SPECTRAL-ANALYSIS; BLOOD-PRESSURE; TIME-DOMAIN; FAILURE; RECEPTOR;
Keywords:
HEART RATE; BRADYCARDIAC AGENTS; HEART RATE VARIABILITY; CHAOTIC BEHAVIOR; CARDIAC HYPERTROPHY; SHR; TRANSGENIC MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
B. Swynghedauw et al., "HEART-RATE AND HEART-RATE-VARIABILITY, A PHARMACOLOGICAL TARGET", Cardiovascular drugs and therapy, 10(6), 1997, pp. 677-685

Abstract

Heart rate varies with respiration, blood pressure, emotion, etc., and heart rate variability (HRV) is presently one of the best indices topredict fatal issues in cardiac failure and after myocardial infarction. HRV depends on various reflexes. In addition, parallel studies of HRV and the myocardial adrenergic and muscarinic transduction system in experimental models of cardiac hypertrophy (CII) have suggested thatthe myocardial phenotype at the sinus-node level may also play a role. A transgenic strain of mice with atrial overexpression of the beta(1)-adrenergic receptors was generated with attenuated HRV, which demonstrates that the phenotype itself is a determinant of HRV. HRV is explored by noninvasive techniques, including simple determination of the standard error of the mean, time-domain analysis, and Fourier transformation. We recently developed a time and frequency domain method of analysis, the smoothed pseudo-Wigner-Ville transformation, which allows better exploration of nonstationarity. Nonlinear methods have also beenapplied due to the extreme complexity of the biological determinants,and have provided evidence of a chaotic attractor in certain conditions. It is proposed that in steady state a very simple process, which is not completely deterministic, could better explain intermit intervalregulations than chaotic behavior. In contrast, under extreme circumstances the regulation proceeds using chaotic behavior. Arrhythmias andHRV can be quantitated in 16-month-old unanesthetized spontaneously hypertensive rats (SHR). Ventricular premature beats are more frequent in SHR than in age-matched controls; they disappear after converting enzyme inhibition (CEI) relative to the reduction of both cardiac hypertrophy and ventricular fibrosis. HRV is attenuated in SHR, as it is incompensatory CII in humans. When CH is prevented, HRV returns to normal. CEI is therefore antiarrhythmic. Another pharmacological application of this concept concerns the bradycardic agents that may improve HRV.

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Documento generato il 28/03/20 alle ore 21:43:02