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Titolo:
INSULIN SENSITIVITY AND LIPID-LEVELS IN OBESE SUBJECTS AFTER SLIMMINGDIETS WITH DIFFERENT COMPLEX AND SIMPLE CARBOHYDRATE CONTENT
Autore:
PIATTI PM; PONTIROLI AE; SAIBENE A; SANTAMBROGIO G; PARONI R; MAGNI F; GALLIKIENLE M; MISTRALI S; MONTI LD; POZZA G;
Indirizzi:
IST SCI SAN RAFFAELE,VIA OLGETTINA 60 I-20132 MILAN ITALY UNIV MILAN,CATTEDRA CLIN MED I-20132 MILAN ITALY UNIV MILAN,SPETTROMETRIA MASSA & HPLC LAB I-20132 MILAN ITALY UNIV MILAN,DIPARTIMENTO BIOCHIM CLIN I-20132 MILAN ITALY
Titolo Testata:
International journal of obesity
fascicolo: 7, volume: 17, anno: 1993,
pagine: 375 - 381
SICI:
0307-0565(1993)17:7<375:ISALIO>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; HUMAN ADIPOSE-TISSUE; SYNTHESIS DE-NOVO; GLUCOSE-METABOLISM; WEIGHT-REDUCTION; FATTY-ACIDS; FIBER; RESISTANCE; BINDING; SERUM;
Keywords:
HIGH COMPLEX CARBOHYDRATE DIET; FIBER; INSULIN SENSITIVITY; INSULIN RELEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
P.M. Piatti et al., "INSULIN SENSITIVITY AND LIPID-LEVELS IN OBESE SUBJECTS AFTER SLIMMINGDIETS WITH DIFFERENT COMPLEX AND SIMPLE CARBOHYDRATE CONTENT", International journal of obesity, 17(7), 1993, pp. 375-381

Abstract

The ideal hypocaloric diet should reduce body weight, decrease fat more than muscle tissue, and ameliorate insulin sensitivity and lipid levels. The aim of this study was to investigate the effect of three hypocaloric diets with different carbohydrate (CHO) and fat contents on body weight reduction, insulin release and sensitivity, and lipid levels in patients with simple obesity. Twenty-five obese subjects with normal glucose tolerance were randomly allocated to three hypocaloric (800 kcal) diets containing: 60% high complex/high starch and fibre (HC/HSF-CHO) and 20% fat (group 1;11 subjects); 60% high simple/high natural fibre (HS/HNF-CHO) and 20% fat (group 2; 7 subjects); or 20% CHO (L-CHO) and 60% fat (group 3; 7 subjects). The remaining 20% of the diet was protein. In all cases the duration of the diet was 21 days. Beforeand after the diet, seven subjects from each group underwent a hyperglycemic clamp, and the other four subjects of group 1 underwent a euglycemic-hyperinsulinemic clamp, combined with a glucose turnover study. A similar decrease in body weight, fat-free mass, fat mass, total cholesterol, LDL cholesterol and apo B levels was observed in the three groups. The M/I ratio during hyperglycemic and euglycemic-hyperinsulinemic clamp and the glucose turnover rate during euglycemic-hyperinsulinemic clamp significantly decreased, and FFA levels significantly increased only after the HC/HSF-CHO diet. HDL cholesterol and apo A1 significantly increased only during the HS/HNF-CHO diet. In conclusion, all hypocaloric diets with different CHO and fat contents can decrease body weight, total cholesterol, LDL cholesterol, and apo B levels; a hypocaloric diet with a HC/HSF-CHO content induces a state of insulin resistance probably mediated by the increased FFA levels; and a hypocaloric diet with HS/HNF-CHO content does not worsen insulin sensitivity, and increases cholesterol and apo A1 levels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:48:38