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Titolo:
SYNTHESIS OF (9R,12S)-CYCLOISODITYROSINE AND (9S,12S)-CYCLOISODITYROSINE AND THEIR N-METHYL DERIVATIVES
Autore:
BOGER DL; ZHOU JC; BORZILLERI RM; NUKUI S; CASTLE SL;
Indirizzi:
SCRIPPS CLIN & RES INST,DEPT CHEM,10550 N TORREY PINES RD LA JOLLA CA92037
Titolo Testata:
Journal of organic chemistry
fascicolo: 7, volume: 62, anno: 1997,
pagine: 2054 - 2069
SICI:
0022-3263(1997)62:7<2054:SO(A(>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
O-G RING; ULLMANN MACROCYCLIZATION REACTION; ANTITUMOR CYCLIC HEXAPEPTIDES; SUBUNIT FUNCTIONAL ROLES; RA-VII; BINDING POCKET; RUBIAE RADIX; DEOXYBOUVARDIN; VANCOMYCIN; PHARMACOPHORE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
D.L. Boger et al., "SYNTHESIS OF (9R,12S)-CYCLOISODITYROSINE AND (9S,12S)-CYCLOISODITYROSINE AND THEIR N-METHYL DERIVATIVES", Journal of organic chemistry, 62(7), 1997, pp. 2054-2069

Abstract

Full details of the synthesis of (9R,12S)- and (9S,12S)-cycloisodityrosine and their N-methyl derivatives are detailed based on an intramolecular nucleophilic aromatic substitution reaction for formation of the key biaryl ether with 14-membered ring macrocyclization. Their comparison with prior samples and the documentation of a facile C9 epimerization within the natural 9S series are described.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 22:15:40