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Titolo:
CYCLOOXYGENASE-2 EXPRESSION IN HUMAN COLON-CANCER CELLS INCREASES METASTATIC POTENTIAL
Autore:
TSUJII M; KAWANO S; DUBOIS RN;
Indirizzi:
VANDERBILT UNIV,MED CTR,DEPT MED GI,MCN C-2104 NASHVILLE TN 37232 VANDERBILT UNIV,MED CTR,CTR MOL TOXICOL,DEPT MED NASHVILLE TN 37232 VANDERBILT UNIV,MED CTR,CTR MOL TOXICOL,DEPT CELL BIOL NASHVILLE TN 37232 OSAKA UNIV,SCH MED,DEPT MED 1 OSAKA 553 JAPAN
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 7, volume: 94, anno: 1997,
pagine: 3336 - 3340
SICI:
0027-8424(1997)94:7<3336:CEIHCC>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; PROSTAGLANDIN G/H SYNTHASE-1; MATRIX METALLOPROTEINASE; COLORECTAL-CANCER; ASPIRIN USE; DIFFERENTIAL INHIBITION; EPITHELIAL-CELLS; TISSUE INHIBITOR; RISK; GENE;
Keywords:
INVASION; METALLOPROTEINASE; PROSTAGLANDINS; SULINDAC SULFIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
M. Tsujii et al., "CYCLOOXYGENASE-2 EXPRESSION IN HUMAN COLON-CANCER CELLS INCREASES METASTATIC POTENTIAL", Proceedings of the National Academy of Sciences of the United Statesof America, 94(7), 1997, pp. 3336-3340

Abstract

Recent epidemiologic studies have shown a 40-50% reduction in mortality from colorectal cancer in individuals who take nonsteroidal antiinflammatory drugs on a regular basis compared with those not taking these agents, One property shared bg all of these drugs is their ability to inhibit cyclooxygenase (COY), a keg enzyme in the conversion of arachidonic acid to prostaglandins. Two isoforms of COX have been characterized, COX-I and COX-2, COX-2 is expressed at high levels in intestinal tumors in humans and rodents, Human colon cancer tells (Caco-2) werepermanently transfected with a COX-2 expression vector or the identical vector lacking the COX-2 insert, The Caco-2 cells, which constitutively expressed COX-2, acquired increased invasiveness compared with the parental Caco-2 cells or the vector transfected control cells. Biochemical changes associated with this phenotypic change included activation of metalloproteinase-2 and increased RNA levels for the membrane-type metalloproteinase, increased invasiveness and prostaglandin production were reversed by treatment with sulindac sulfide, a known COX inhibitor, These studies demonstrate that constitutive expression of COX-2 can lead to phenotypic changes that alter the metastatic potential of colorectal cancer cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 18:41:57