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Titolo:
DETECTION OF 32ND COGNITIVE ACTIVATIONS IN SINGLE SUBJECTS WITH POSITRON EMISSION TOMOGRAPHY - A NEW LOW-DOSE (H2O)-O-15 REGIONAL CEREBRAL BLOOD-FLOW 3-DIMENSIONAL IMAGING TECHNIQUE
Autore:
SILBERSWEIG DA; STERN E; FRITH CD; CAHILL C; SCHNORR L; GROOTOONK S; SPINKS T; CLARK J; FRACKOWIAK R; JONES T;
Indirizzi:
HAMMERSMITH HOSP,MRC,CYCLOTRON UNIT,DUCANE RD LONDON W12 0HS ENGLAND CORNELL UNIV,MED CTR,NEW YORK HOSP,DEPT NEUROL & NEUROSCI NEW YORK NY10021 CORNELL UNIV,MED CTR,NEW YORK HOSP,DEPT RADIOL NEW YORK NY 10021 CORNELL UNIV,MED CTR,NEW YORK HOSP,DEPT PSYCHIAT,PAYNE WHITNEY CLIN NEW YORK NY 10021
Titolo Testata:
Journal of cerebral blood flow and metabolism
fascicolo: 4, volume: 13, anno: 1993,
pagine: 617 - 629
SICI:
0271-678X(1993)13:4<617:DO3CAI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAVENOUS (H2O)-O-15; ERROR ANALYSIS; PET SCANNER; HUMAN-BRAIN; COMPREHENSION; LOCALIZATION; NETWORKS; CORTEX; WATER;
Keywords:
FUNCTIONAL BRAIN IMAGING; O-15-LABELED WATER; POSITRON EMISSION TOMOGRAPHY; REGIONAL CEREBRAL BLOOD FLOW; SINGLE-SUBJECT ANALYSIS; SLOW BOLUS TECHNIQUE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
D.A. Silbersweig et al., "DETECTION OF 32ND COGNITIVE ACTIVATIONS IN SINGLE SUBJECTS WITH POSITRON EMISSION TOMOGRAPHY - A NEW LOW-DOSE (H2O)-O-15 REGIONAL CEREBRAL BLOOD-FLOW 3-DIMENSIONAL IMAGING TECHNIQUE", Journal of cerebral blood flow and metabolism, 13(4), 1993, pp. 617-629

Abstract

Positron emission tomography regional CBF (rCBF) studies of cognitiveprocesses have traditionally required 30-60 mCi of (H2O)-O-15 per scan and intersubject averaging to achieve statistical significance. However, intersubject anatomical, functional, and disease variability can make such an approach problematic. A new method that produces significant results in single subjects is presented. It is based upon high-sensitivity three-dimensional imaging and a ''slow'' bolus administrationof < 15 mCi of (H2O)-O-15 per scan. The method is validated in four normal volunteers using control and auditory-language activation tasks with four scans per condition and statistical parametric mapping analysis. It is demonstrated that the rCBF distribution associated with thecognitive state is detected during the arrival of radiotracer in the brain. This occurs over 30 s and constitutes a critical temporal window during which stimulation should be performed. A 90-s acquisition time is found to produce results of greater significance than a 60-s acquisition time. The implications of the results and the functional neuroanatomical findings are discussed. This method is suitable for the study of individual functional neuroanatomy in many neuropsychological, pharmacologic, and symptom states in normal subjects and in patients with psychiatric and neurologic disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 18:57:39