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Titolo:
HLA-DQ PRIMARILY CONFERS PROTECTION AND HLA-DR SUSCEPTIBILITY IN TYPE-I (INSULIN-DEPENDENT) DIABETES STUDIED IN POPULATION-BASED AFFECTED FAMILIES AND CONTROLS
Autore:
KOCKUM I; WASSMUTH R; HOLMBERG E; MICHELSEN B; LERNMARK A;
Indirizzi:
KAROLINSKA INST,KAROLINSKA HOSP,DEPT ENDOCRINOL S-10401 STOCKHOLM 60 SWEDEN KAROLINSKA INST,KAROLINSKA HOSP,DEPT ENDOCRINOL S-10401 STOCKHOLM 60 SWEDEN UNIV WASHINGTON,DEPT MED,RH WILLIAMS LAB SEATTLE WA 98195 LUND UNIV,WALLENBERG LAB S-22101 LUND SWEDEN UNIV ERLANGEN NURNBERG,MED KLIN 3 W-8520 ERLANGEN GERMANY UMEA UNIV,DEPT PEDIAT S-90187 UMEA SWEDEN HAGEDORN RES LAB GENTOFTE DENMARK
Titolo Testata:
American journal of human genetics
fascicolo: 1, volume: 53, anno: 1993,
pagine: 150 - 167
SICI:
0002-9297(1993)53:1<150:HPCPAH>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
FRAGMENT-LENGTH-POLYMORPHISM; BETA-CHAIN; GENETIC SUSCEPTIBILITY; ASPARTIC-ACID; RESTRICTION FRAGMENTS; IDDM PATIENTS; A ANTIGENS; MELLITUS; HAPLOTYPES; JAPANESE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
67
Recensione:
Indirizzi per estratti:
Citazione:
I. Kockum et al., "HLA-DQ PRIMARILY CONFERS PROTECTION AND HLA-DR SUSCEPTIBILITY IN TYPE-I (INSULIN-DEPENDENT) DIABETES STUDIED IN POPULATION-BASED AFFECTED FAMILIES AND CONTROLS", American journal of human genetics, 53(1), 1993, pp. 150-167

Abstract

The association between HLA-DR and -DQ and insulin-dependent diabetesmellitus (IDDM) in a defined high-incidence area was analyzed in a total of 58 population-based patients, representing 77% of IDDM patientswith age at onset below 16 years, and in 92 unrelated parents in control families without IDDM. HLA haplotypes were confirmed by analyzing first-degree relatives in both groups. Seven different methods were used to analyze risk: (1) odds ratio, (2) absolute risk, (3) haplotype relative risk, (4) transcomplementation relative risk, (5) relative predisposing effects, (6) stratification analysis, and (7) test of predisposing allele on haplotype. DQB10302 indicated somewhat higher risk than did DR4, while DR3 had a higher risk than DQB10201; however, the 95% confidence intervals of the risk estimates overlapped. The positive association between IDDM and the DQB10201-DQA1*0501-DR3 haplotype seems to be due to DR3 or to an unknown linked gene. More important, DQA10301 was present among 93% of the patients, and this allele in various transcomplementation combinations with DQB1 alleles showed closer association to IDDM than did any other alleles. The strong negative association of the DQB10602 allele also in the presence of either DR4 or DQB10302 or both suggests that, in a high-risk population for IDDM,HLA-DQ primarily confers protection, perhaps by induction of tolerance. Consistent with known functions, HLA-DR may primarily confer susceptibility, perhaps by induction of autoreactive T lymphocytes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 00:23:30