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Titolo:
SELF-STABILIZED ANTISENSE OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATES - PROPERTIES AND ANTI-HIV ACTIVITY
Autore:
TANG JY; TEMSAMANI J; AGRAWAL S;
Indirizzi:
HYBRIDON INC,1 INNOVAT DR WORCESTER MA 01605 HYBRIDON INC,1 INNOVAT DR WORCESTER MA 01605
Titolo Testata:
Nucleic acids research
fascicolo: 11, volume: 21, anno: 1993,
pagine: 2729 - 2735
SICI:
0305-1048(1993)21:11<2729:SAOP-P>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; CHRONICALLY INFECTED-CELLS; INHIBITION; OLIGODEOXYRIBONUCLEOTIDES; OLIGONUCLEOTIDES; REPLICATION; EXPRESSION; ANALOGS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
J.Y. Tang et al., "SELF-STABILIZED ANTISENSE OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATES - PROPERTIES AND ANTI-HIV ACTIVITY", Nucleic acids research, 21(11), 1993, pp. 2729-2735

Abstract

A new class of oligodeoxyribonucleotides has been designed, referred to here as 'self-stabilized' oligonucleotides. These oligonucleotides have hairpin loop structures at their 3' ends, and show increased resistance to degradation by snake venom phosphodiesterase, DNA polymeraseI and fetal bovine serum. The self-stabilized region of the oligonucleotide does not interfere In hybridization with complementary nucleic acids as shown by melting temperature, mobility-shift and RNase H cleavage studies. Various self-stabilized oligonucleotides containing increasingly stable hairpin loop regions were studied for their anti-HIV activity. Pharmacokinetic and stability studies in mice showed increased in vivo persistence of self-stabilized oligonucleotides with respectto their linear counterparts.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 23:43:56