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Titolo:
EFFECT OF AGING ON CHOLESTEROL 7-ALPHA-HYDROXYLATION IN HUMANS
Autore:
BERTOLOTTI M; ABATE N; BERTOLOTTI S; LORIA P; CONCARI M; MESSORA R; CARUBBI F; PINETTI A; CARULLI N;
Indirizzi:
UNIV MODENA POLICLIN,IST PATOL MED CLIN MED 1,VIA POZZO 71 I-41100 MODENA ITALY OSPED GIOVANNI 23,DIV GERIATRIA I-42010 ALBINEA ITALY UNIV MODENA,IST PATOL MED I-41100 MODENA ITALY UNIV MODENA,IST CHIM ORGAN I-41100 MODENA ITALY
Titolo Testata:
Journal of lipid research
fascicolo: 6, volume: 34, anno: 1993,
pagine: 1001 - 1007
SICI:
0022-2275(1993)34:6<1001:EOAOC7>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
BILE-ACID METABOLISM; QUANTITATIVE ESTIMATION; URSODEOXYCHOLIC ACID; AGE; LIVER; SERUM; RAT; 7ALPHA-HYDROXYLASE; INVIVO;
Keywords:
BILE ACID SYNTHESIS; CHOLESTEROL HOMEOSTASIS; PLASMA CHOLESTEROL; PLASMA TRIGLYCERIDES; BILE ACID POOL; CHOLESTYRAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
M. Bertolotti et al., "EFFECT OF AGING ON CHOLESTEROL 7-ALPHA-HYDROXYLATION IN HUMANS", Journal of lipid research, 34(6), 1993, pp. 1001-1007

Abstract

In order to investigate the alterations of bile acid synthesis in aging, we studied the rates of cholesterol 7alpha-hydroxylation, the rate-limiting step, in 28 patients of different ages (34-83 years old, 14 below and 14 above the age of 65) of both sexes. Hydroxylation rates were determined by tritium release assay after an intravenous bolus of [7alpha-H-3]cholesterol. Cholesterol 7alpha-hydroxylation was significantly decreased in the older age group, compared to middle-aged subjects, both in males and females; moreover, a significant inverse correlation between hydroxylation rates and age was found in the whole sample(r = -0.56; P < 0.01) and in females, but not in males. The percent concentration of deoxycholic acid in plasma (determined by gas-liquid chromatography) was increased in older subjects. Plasma cholesterol andtriglyceride levels were not related with age even though triglyceride concentrations tended to be lower in the older age group. Triglyceride, but not cholesterol levels, were directly correlated with hydroxylation rates (r = 0.45, P < 0.05). After cholestyramine treatment (8-12g/day for 4 weeks) a sharp increase in 7alpha-hydroxylation rates wasobserved in three elderly patients, accompanied by reduced levels of dihydroxylated bile acids. Our data are consistent with a reduced rateof conversion of cholesterol to bile acids with aging, particularly in females, and suggest a coordinate reduction of triglyceride production. Alterations of the quantitative and/or qualitative pattern of the bile acid pool recirculating to the liver may be responsible, at leastin part, for the changes observed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 02:38:19