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Titolo:
PENTYLENETETRAZOL SEIZURES INCREASE PRO-NERVE GROWTH FACTOR-LIKE IMMUNOREACTIVITY IN THE RETICULAR THALAMIC NUCLEUS AND NERVE GROWTH-FACTORMESSENGER-RNA IN THE DENTATE GYRUS
Autore:
HUMPEL C; EBENDAL T; CAO Y; OLSON L;
Indirizzi:
KAROLINSKA INST,DEPT HISTOL & NEUROBIOL,POB 60400 S-10401 STOCKHOLM 60 SWEDEN KAROLINSKA INST,LUDWIG INST CANC RES S-10401 STOCKHOLM 60 SWEDEN UNIV UPPSALA,DEPT DEV BIOL S-75105 UPPSALA SWEDEN
Titolo Testata:
Journal of neuroscience research
fascicolo: 4, volume: 35, anno: 1993,
pagine: 419 - 427
SICI:
0360-4012(1993)35:4<419:PSIPGF>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR-IONOPHORE COMPLEX; NEUROTROPHIC FACTOR; RAT-BRAIN; PHYSIOLOGICAL-ROLE; NEONATAL RATS; FACTOR FAMILY; EXPRESSION; LOCALIZATION; HIPPOCAMPUS; PROTEIN;
Keywords:
KINDLING; NEUROTROPHINS; NERVE GROWTH FACTOR PRECURSOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
C. Humpel et al., "PENTYLENETETRAZOL SEIZURES INCREASE PRO-NERVE GROWTH FACTOR-LIKE IMMUNOREACTIVITY IN THE RETICULAR THALAMIC NUCLEUS AND NERVE GROWTH-FACTORMESSENGER-RNA IN THE DENTATE GYRUS", Journal of neuroscience research, 35(4), 1993, pp. 419-427

Abstract

Neurotrophins may have a neuroprotective role and are probably involved in the control of axonal sprouting and synaptic plasticity. An antibody raised against a pro-sequence of nerve growth factor (NGF) was tested. In control undisturbed rats, a strong immunoreactivity was detected in scattered cells in and around the pyramidal and granule cell layer of the hippocampus and a moderate labeling was found in the reticular thalamic nucleus. In situ hybridization showed specific expressionof NGF mRNA in a similar population of scattered cells in the hippocampal formation but not in the reticular thalamic nucleus. Acute epileptic seizures, induced by a convulsive dose of 50 mg/kg pentylenetetrazol (PTZ), strongly increased NGF mRNA in neurons of the granular layerof the dentate gyrus 3 hr but not 6 hr after the injection. No changein pro-NGF-like immunoreactivity was observed in the hippocampus or reticular thalamic nucleus after acute seizures. Chemical kindling was induced by daily injections of subconvulsive doses (30 mg/kg) of PTZ for 4 weeks. This treatment significantly increased pro-NGF-like immunoreactivity in the reticular thalamic nucleus but did not affect NGF mRNA. These data strengthen a role for the reticular thalamic nucleus and NGF in PTZ kindling.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 08:17:03