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Titolo:
HYPERPNEA-INDUCED CHANGES IN PARENCHYMAL LUNG-MECHANICS IN NORMAL SUBJECTS AND IN ASTHMATICS
Autore:
KAMINSKY DA; WENZEL SE; CARCANO C; GURKA D; FELDSIEN D; IRVIN CG;
Indirizzi:
UNIV VERMONT,COLL MED,PULM DIS & CRIT CARE MED UNIT,GIVEN C-317 BURLINGTON VT 05405 NATL JEWISH CTR IMMUNOL & RESP MED DENVER CO 80206 UNIV COLORADO,HLTH SCI CTR,DIV PULM SCI & CRIT CARE MED DENVER CO 80202
Titolo Testata:
American journal of respiratory and critical care medicine
fascicolo: 4, volume: 155, anno: 1997,
pagine: 1260 - 1266
SICI:
1073-449X(1997)155:4<1260:HCIPLI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAXIMAL EXPIRATORY FLOW; EXERCISE-INDUCED ASTHMA; PERIPHERAL AIRWAYS; VOLUME HISTORY; NARROW TUBE; HYSTERESIS; SURFACTANT; CONSTRICTION; CURVE; AIR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
D.A. Kaminsky et al., "HYPERPNEA-INDUCED CHANGES IN PARENCHYMAL LUNG-MECHANICS IN NORMAL SUBJECTS AND IN ASTHMATICS", American journal of respiratory and critical care medicine, 155(4), 1997, pp. 1260-1266

Abstract

The effects of hyperpnea an parenchymal lung mechanics are unknown, but they may contribute to the resultant airflow limitation commonly seen in asthma. To investigate these effects, we measured the following parameters in seven asthmatic and six normal subjects before and after5 min of hyperpnea: specific conductance, upstream resistance, staticcompliance, the coefficient of retraction, lung volumes, lung hysteresis, and the ratio of maximal to partial flow rates (the M:P ratio, anindicator of the effect of deep inhalation on airflow, and a measure of relative airway and parenchymal hysteresis). In addition to a central effect on the airways, as shown by significant: falls in specific conductance, hyperpnea in asthmatics, but not in normal subjects, resulted in significant increases in residual volume and pressure-volume hysteresis, suggestive of changes in parenchymal lung mechanics. The M:Pratio also increased In the asthmatics, consistent with greater increases in airway than in parenchymal hysteresis after hyperpnea. We conclude that hyperpnea has significant effects on the lung parenchyma that contribute to airflow limitation in asthmatics, and we hypothesize that these effects may be due to alterations in peripheral airway smooth muscle tone and surfactant function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:27:27