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Titolo:
PREVENTION OF RHINOVIRUS INFECTION IN CHIMPANZEES BY SOLUBLE INTERCELLULAR-ADHESION MOLECULE-1
Autore:
HUGUENEL ED; COHN D; DOCKUM DP; GREVE JM; FOURNEL MA; HAMMOND L; IRWIN R; MAHONEY J; MCCLELLAND A; MUCHMORE E; OHLIN AC; SCUDERI P;
Indirizzi:
BAYER RES CTR,DIV PHARMACEUT,400 MORGAN LANE W HAVEN CT 06516 NYU,LAB EXPT MED & SURG PRIMATES,MED CTR TUXEDO PK NY 00000 WHITE SANDS RES CTR ALAMOGORDO NM 00000 BAYER CORP BERKELEY CA 00000
Titolo Testata:
American journal of respiratory and critical care medicine
fascicolo: 4, volume: 155, anno: 1997,
pagine: 1206 - 1210
SICI:
1073-449X(1997)155:4<1206:PORIIC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRANASAL ALPHA-2-INTERFERON; ASTHMA SYMPTOMS; COLDS; RECEPTOR; ICAM-1; VOLUNTEERS; EFFICACY; EXACERBATIONS; PRECIPITANTS; PROPHYLAXIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
E.D. Huguenel et al., "PREVENTION OF RHINOVIRUS INFECTION IN CHIMPANZEES BY SOLUBLE INTERCELLULAR-ADHESION MOLECULE-1", American journal of respiratory and critical care medicine, 155(4), 1997, pp. 1206-1210

Abstract

Intercellular adhesion molecule-1 (ICAM-1) is the cell surface receptor for the major class of human rhinoviruses, and tICAM(453), a truncated, soluble form of ICAM-1, has been shown previously to be a patent in vitro inhibitor of rhinovirus, in this report, we have investigatedthe in vivo efficacy of tICAM(453) for the prophylaxis of rhinovirus serotype 16 infection in the chimpanzee. Because chimpanzees do not show clinical symptoms of infection after rhinovirus challenge, infection was followed lay measuring antirhinovirus serum antibody responses and detection of virus shedding. By hath of these measures, intranasal application of tICAM(453) was efficacious in preventing rhinovirus infection in chimpanzees subsequently challenged with infectious doses ofvirus. These results suggest that the use of soluble rhinovirus receptor to inhibit virus binding to host cells should be feasible in humans.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 11:31:40