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Titolo:
COMPARISON OF CONTINUOUS MICROPERFUSION AND COLD-STORAGE FOR PIG-HEART PRESERVATION
Autore:
FERRERA R; MARCSEK P; LARESE A; GIRARD C; GUIDOLLET J; DITTMAR A; DUREAU G;
Indirizzi:
FAC MED LYON,THERMOREGULAT LAB,CNRS,URA 1341,8 AV ROCKEFELLER F-69373LYON 08 FRANCE
Titolo Testata:
The Journal of heart and lung transplantation
fascicolo: 3, volume: 12, anno: 1993,
pagine: 463 - 469
SICI:
1053-2498(1993)12:3<463:COCMAC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
R. Ferrera et al., "COMPARISON OF CONTINUOUS MICROPERFUSION AND COLD-STORAGE FOR PIG-HEART PRESERVATION", The Journal of heart and lung transplantation, 12(3), 1993, pp. 463-469

Abstract

The aim of this study was to compare two methods of hypothermic heartpreservation. Isolated hearts of pigs were preserved in cold cardioplegic solution (St. Thomas Hospital solution) either by simple storage or continuous microperfusion (with a new perfusion device) for 6 hours(group I, n = 12), 12 hours (group II, n = 12) and 24 hours (group III, n = 12). After storage, the myocardial function was studied for 60 minutes under nonworking conditions with an ex vivo functional testingsystem. Hearts preserved 24 hours by cold storage (group III) showed ventricular compliance and mean spontaneous left ventricular developedpressure significantly lower than hearts preserved by microperfusion (respectively, 63 +/- 47 versus 14 +/- 18 mm Hg and 16.8 +/- 22.0 versus 83 +/- 33 mm Hg). After 12 hours (group II) of preservation, mean left ventricular developed pressure was higher in microperfused hearts compared to immersed hearts (respectively, 133.3 +/- 39.0 versus 83.1 /- 27.0 mm Hg, p < 0.05), whereas after 6 hours of preservation, no functional difference was observed between the microperfused and the immersed hearts. Hearts were also studied using myocardial biopsy specimens taken at the end of the preservation. The biopsy specimens were analyzed for high-energy phosphates. After 6 hours of preservation, the microperfusion group showed higher levels of adenosine triphosphate and total adenine nucleotides (adenosine triphosphate + adenosine diphosphate + adenosine monophosphate) (respectively, 4.60 +/- 0.5 mumol/gm and 5.98 +/- 0.5 mumol/gm fresh tissue) versus the cold storage group (respectively, 3.10 +/- 0.4 mumol/gm and 3.75 +/- 0.4 mumol/gm). Thesestudies show the beneficial effect of the microperfusion apparatus compared to immersion for long-term heart preservation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 16:13:59