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Titolo:
MUTATION, CANCER AND TRANSGENIC MODELS - RELEVANCE TO THE TOXICOLOGY INDUSTRY
Autore:
SULLIVAN N; GATEHOUSE D; TWEATS D;
Indirizzi:
GLAXO GRP RES LTD,DEPT GENET & REPROD TOXICOL WARE SG12 0DP HERTS ENGLAND GLAXO GRP RES LTD,DEPT GENET & REPROD TOXICOL WARE SG12 0DP HERTS ENGLAND UNIV CAMBRIDGE,INST BIOTECHNOL CAMBRIDGE CB2 1QT ENGLAND
Titolo Testata:
Mutagenesis
fascicolo: 3, volume: 8, anno: 1993,
pagine: 167 - 174
SICI:
0267-8357(1993)8:3<167:MCATM->2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCISION REPAIR GENE; C-MYC PROTEIN; DNA-REPAIR; CELL-LINES; XERODERMA-PIGMENTOSUM; RODENT CARCINOGENS; TUMOR INITIATION; RAS ONCOGENES; B-CELLS; HA-RAS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
89
Recensione:
Indirizzi per estratti:
Citazione:
N. Sullivan et al., "MUTATION, CANCER AND TRANSGENIC MODELS - RELEVANCE TO THE TOXICOLOGY INDUSTRY", Mutagenesis, 8(3), 1993, pp. 167-174

Abstract

The number and structural diversity of new compounds that are currently being introduced into the environment underlies the need to providemore sensitive toxicology tests. Ideally, these should involve tests that reduce dependence upon animal experimentation; over the past few years a step towards achieving this goal has arisen from the ability to construct transgenic animals. By the inclusion of a suitable marker gene or genetic predisposition to a given disease state, several potentially valuable new tests have become available. Here we assess the potential of these systems for use by the toxicologist and consider the future of this technology to the industry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 21:18:35