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Titolo:
BLOCKADE OF TOLERANCE TO MORPHINE BUT NOT TO KAPPA-OPIOIDS BY A NITRIC-OXIDE SYNTHASE INHIBITOR
Autore:
KOLESNIKOV YA; PICK CG; CISZEWSKA G; PASTERNAK GW;
Indirizzi:
CORNELL UNIV,MEM SLOAN KETTERING CANC CTR,COLL MED,DEPT NEUROL NEW YORK NY 10021 CORNELL UNIV,MEM SLOAN KETTERING CANC CTR,DEPT PHARMACOL NEW YORK NY 10021 CORNELL UNIV,MEM SLOAN KETTERING CANC CTR,DEPT NEUROSCI NEW YORK NY 10021
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 11, volume: 90, anno: 1993,
pagine: 5162 - 5166
SICI:
0027-8424(1993)90:11<5162:BOTTMB>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
NALOXONE BENZOYLHYDRAZONE; OPIATE ANALGESIA; BINDING-SITES; ANTAGONIST; MESSENGER; BRAIN; CHOLECYSTOKININ; POTENTIATION; DEPENDENCE; ACTIVATION;
Keywords:
NITRIC OXIDE; OPIATE; DEPENDENCE; NALOXONE BENZOYLHYDRAZONE; U50,488H;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
Y.A. Kolesnikov et al., "BLOCKADE OF TOLERANCE TO MORPHINE BUT NOT TO KAPPA-OPIOIDS BY A NITRIC-OXIDE SYNTHASE INHIBITOR", Proceedings of the National Academy of Sciences of the United Statesof America, 90(11), 1993, pp. 5162-5166

Abstract

The nitric oxide synthase inhibitor N(G)-nitro-L-arginine (NO2Arg) blocks morphine tolerance in mice. After implantation of morphine pellets the analgesic response decreases from 100% on the first day to 0% onthe third. Coadministration of NO2Arg along with the pellets markedlyretards the development of tolerance; 60% of mice are analgesic after3 days, and 50% of mice are analgesic after 5 days. In a daily injection paradigm the analgesic response to morphine is reduced from 60% to0% by 5 days. Concomitant administration of morphine along with NO2Arg at doses of 2 mg/kg per day prevents tolerance for 4 weeks. A singleNO2Arg dose retards morphine tolerance for several days, and dosing every 4 days is almost as effective as daily NO2Arg. NO2Arg slowly reverses preexisting tolerance over 5 days despite the continued administration of morphine along with NO2Arg. NO2Arg also reduces dependence and reverses previously established dependence. NO2Arg does not prevent tolerance to analgesia mediated by the kappa1 agonist -[2-(1-pyrrolindinyl)cyclohexyl]-benzene-acetamide (U50,488H) or the kappa3 agent naloxone benzoylhydrazone, indicating a selective action of NO in the mechanisms of mu tolerance and dependence.

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Documento generato il 13/07/20 alle ore 11:12:11