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Titolo:
AN ELECTROSTATIC MECHANISM FOR SUBSTRATE GUIDANCE DOWN THE AROMATIC GORGE OF ACETYLCHOLINESTERASE
Autore:
RIPOLL DR; FAERMAN CH; AXELSEN PH; SILMAN I; SUSSMAN JL;
Indirizzi:
CORNELL UNIV,CORNELL THEORY CTR ITHACA NY 14853 NATL RES COUNCIL CANADA,MOLEC BIOL BIOTECHNOL RES INST MONTREAL H4P 2R2 PQ CANADA WEIZMANN INST SCI,DEPT STRUCT BIOL IL-76100 REHOVOT ISRAEL WEIZMANN INST SCI,DEPT NEUROBIOL IL-76100 REHOVOT ISRAEL
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 11, volume: 90, anno: 1993,
pagine: 5128 - 5132
SICI:
0027-8424(1993)90:11<5128:AEMFSG>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
TORPEDO-CALIFORNICA; PROTEINS; BINDING; CHARGE; SUPEROXIDE; DYNAMICS; COPPER; SITE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
D.R. Ripoll et al., "AN ELECTROSTATIC MECHANISM FOR SUBSTRATE GUIDANCE DOWN THE AROMATIC GORGE OF ACETYLCHOLINESTERASE", Proceedings of the National Academy of Sciences of the United Statesof America, 90(11), 1993, pp. 5128-5132

Abstract

Electrostatic calculations based on the recently solved crystal structure of acetylcholinesterase (acetylcholine acetylhydrolase, EC 3.1.1.7) indicate that this enzyme has a strong electrostatic dipole. The dipole is aligned with the gorge leading to its active site, so that a positively charged substrate will be drawn to the active site by its electrostatic field. Within the gorge, aromatic side chains appear to shield the substrate from direct interaction with most of the negativelycharged residues that give rise to the dipole. The affinity of quaternary ammonium compounds for aromatic rings, coupled with this electrostatic force, may work in concert to create a selective and efficient substrate-binding site in acetylcholinesterase and explain why the active site is situated at the bottom of a deep gorge lined with aromatic residues.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 06:03:49