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Titolo:
THERAPY FOR METASTATIC MELANOMA - EFFECTIVE COMBINATION OF DACARBAZINE, CARMUSTINE, CISPLATIN AND TAMOXIFEN
Autore:
FIERRO MT; BERTERO M; NOVELLI M; APPINO A; DOVEIL GC; COLONNA S; BERNENGO MG;
Indirizzi:
UNIV TURIN,DERMATOL CLIN,VIA CHERASCO 23 I-10126 TURIN ITALY UNIV TURIN,DERMATOL CLIN,VIA CHERASCO 23 I-10126 TURIN ITALY
Titolo Testata:
Melanoma research
fascicolo: 2, volume: 3, anno: 1993,
pagine: 127 - 131
SICI:
0960-8931(1993)3:2<127:TFMM-E>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Keywords:
CHEMOTHERAPY; CISPLATIN; METASTATIC MELANOMA; TAMOXIFEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
M.T. Fierro et al., "THERAPY FOR METASTATIC MELANOMA - EFFECTIVE COMBINATION OF DACARBAZINE, CARMUSTINE, CISPLATIN AND TAMOXIFEN", Melanoma research, 3(2), 1993, pp. 127-131

Abstract

Thirty-two patients with metastatic melanoma received combination chemotherapy and hormonal therapy. Treatment included Carmustine, Cisplatin, Dacarbazine and Tamoxifen (BCDT). The overall response rate was 47%: five patients had a complete response (16%), 10 patients had a partial response (31%) and two had no response (6%). The median survival for responders was 10 months (range 2-20). The BCDT regimen was equallyeffective against soft tissue and visceral metastases. Neither survival or response rate was modified by pretreatment with alpha-interferon(alpha-IFN). In agreement with the results of a recent randomized trial comparing the efficacy of Dacarbazine with that of Dacarbazine plusTamoxifen, a better survival was found in women than in men: althoughthe response rate was identical (47%), the median duration of response was higher for women. A fall in serum soluble IL-2 receptor (sIL-2R)levels after therapy was seen in responding patients, confirming the usefulness of this parameter in monitoring disease evolution.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 03:42:03