Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
HOE-694, A NEW NA+ H+ EXCHANGE INHIBITOR AND ITS EFFECTS IN CARDIAC ISCHEMIA/
Autore:
SCHOLZ W; ALBUS U; LANG HJ; LINZ W; MARTORANA PA; ENGLERT HC; SCHOLKENS BA;
Indirizzi:
HOECHST AG,POSTFACH 800320 W-6230 FRANKFURT 80 GERMANY
Titolo Testata:
British Journal of Pharmacology
fascicolo: 2, volume: 109, anno: 1993,
pagine: 562 - 568
SICI:
0007-1188(1993)109:2<562:HANNHE>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-HEART; INTRACELLULAR PH; INTERNAL PH; H+ EXCHANGE; CELLS; SYSTEM; AMILORIDE; PLATELETS; SODIUM; MYOCARDIUM;
Keywords:
HOE-694; NA+/H+ EXCHANGE, ISCHEMIA; ARRHYTHMIA, CARDIAC PROTECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
W. Scholz et al., "HOE-694, A NEW NA+ H+ EXCHANGE INHIBITOR AND ITS EFFECTS IN CARDIAC ISCHEMIA/", British Journal of Pharmacology, 109(2), 1993, pp. 562-568

Abstract

1 The benzoylguanidine derivative Hoe 694 ((3-methylsulphonyl-4-piperidino-benzoyl) guanidine methanesulphonate) was characterized as an inhibitor of Na+/H+ exchange in rabbit erythrocytes, rat platelets and bovine endothelial cells. The potency of the compound was slightly lower or comparable to ethylisopropyl amiloride (EIPA). 2 To investigate apossible cardioprotective role of the Na+/H+ exchange inhibitor Hoe 694, rat isolated working hearts were subjected to ischaemia and reperfusion. In these experiments all untreated hearts suffered ventricular fibrillation on reperfusion. Addition of 10(-7) M Hoe 694 to the perfusate almost abolished reperfusion arrhythmias in the rat isolated working hearts. 3 Hoe 694 reduced the release of lactate dehydrogenase (LDH) and creatine kinase (CK), which are indicators of cellular damage during ischaemia, into the venous effluent of the hearts by 60% and 54%, respectively. 4 The tissue content of glycogen at the end of the experiments was increased by 60% and the high energy phosphates ATP and creatine phosphate were increased by 240% and 270% respectively in the treated hearts as compared to control hearts.. 5 Antiischaemic effectsof the Na+/H+ exchange inhibitor, Hoe 694, were investigated in a second experiment in anaesthetized rats undergoing coronary artery ligation. In these animals, pretreatment with Hoe 694 caused a dose-dependent reduction of ventricular premature beats and ventricular tachycardiaas well as a complete suppression of ventricular fibrillation down todoses of 0.1 mg kg-1, i.v. Blood pressure and heart rate remained unchanged. 6 We conclude that the new Na+/H+ exchange inhibitor, Hoe 694,shows cardioprotective and antiarrhythmic effects in ischaemia and reperfusion in rat isolated hearts and in anaesthetized rats. In view ofthe role which Na+/H+ exchange seems to play in the pathophysiology of cardiac ischaemia these effects could probably be attributed to Na+/H+ exchange inhibition.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 22:06:00