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Titolo:
FUNCTIONAL IMPORTANCE OF CHOLINERGIC AND PURINERGIC NEUROTRANSMISSIONFOR MICTURITION CONTRACTION IN THE NORMAL, UNANESTHETIZED RAT
Autore:
IGAWA Y; MATTIASSON A; ANDERSSON KE;
Indirizzi:
UNIV LUND HOSP,DEPT UROL S-22185 LUND SWEDEN UNIV LUND HOSP,DEPT CLIN PHARMACOL S-22185 LUND SWEDEN SHINSHU UNIV,SCH MED,DEPT UROL MATSUMOTO NAGANO 390 JAPAN
Titolo Testata:
British Journal of Pharmacology
fascicolo: 2, volume: 109, anno: 1993,
pagine: 473 - 479
SICI:
0007-1188(1993)109:2<473:FIOCAP>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
PIG URINARY-BLADDER; NONCHOLINERGIC NEUROGENIC RESPONSES; GUINEA-PIG; ALPHA,BETA-METHYLENE ATP; ADENOSINE-TRIPHOSPHATE; FIELD STIMULATION; RABBIT; ATROPINE; TRANSMISSION; MUSCLE;
Keywords:
MICTURITION IN RAT; CHOLINERGIC TRANSMISSION; PURINERGIC TRANSMISSION; CYSTOMETRY; ALPHA,BETA-METHYLENE ATP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
Y. Igawa et al., "FUNCTIONAL IMPORTANCE OF CHOLINERGIC AND PURINERGIC NEUROTRANSMISSIONFOR MICTURITION CONTRACTION IN THE NORMAL, UNANESTHETIZED RAT", British Journal of Pharmacology, 109(2), 1993, pp. 473-479

Abstract

1 The cholinergic and purinergic neurotransmission involved in micturition in the normal, unanaesthetized rat was investigated by means of continuous cystometry. 2 ATP (1 and 5 mg kg-1), administered intra-arterially (i.a.) close to the bladder, produced rapid, phasic, dose-dependent increases in bladder pressure with micturition immediately afterinjection. The micturition pressure of the following spontaneous voidings increased, and bladder capacity, micturition volume, and residualvolume decreased. Pretreatment with alpha,beta-methylene ATP (I mg kg-1, i.a.) blocked the effects of ATP (5 mg kg-1). 3 alpha,beta-Methylene ATP (0.25, 0.5 and 1 mg kg-1, i.a.) produced rapid, phasic, increases in bladder pressure with micturition immediately after injection. The effects of alpha,beta-methylene ATP (0.25 mg kg-1, i.a.) were not affected by pretreatment with indomethacin (0.5-2 mg kg-1, i.a.). The micturition pressure of the subsequent spontaneous voidings decreased, and bladder capacity and residual volume increased. 4 Carbachol (5-50 mug kg-1, i.a.) produced rapid, sustained, dose-dependent increases inbladder pressure with micturition, and then increased basal pressure,threshold pressure, and micturition pressure, and decreased bladder capacity and micturition volume during the following spontaneous voidings. 5 Atropine (1 mg kg-1, i.a.) decreased micturition pressure and micturition volume, but did not induce dribbling incontinence. Micturition contractions still occurred after the injection, but changed in appearance and were of shorter duration than before. In the presence of atropine (I mg kg-1, i.a.), alpha,beta-methylene ATP (1 mg kg-1, i.a.) produced initially a phasic increase in bladder pressure with micturition and then dribbling incontinence in all animals tested. 6 After blockade of the micturition reflex with morphine (10 mug intrathecally), ATP (5 mg kg-1, i.a.), alpha,beta-methylene ATP (0.25-1 mg kg-1, i.a.), and carbachol (5-500 mug kg-1, i.a.) were unable to empty the bladder. 7 The results suggest that drug-induced bladder emptying in the normal, unanaesthetized rat requires an intact micturition reflex and they support the view that the two physiologically important transmittersinvolved in micturition are acetylcholine and ATP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 07:17:34