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Titolo:
HYPERGLYCEMIC PSEUDOHYPOXIA AND DIABETIC COMPLICATIONS
Autore:
WILLIAMSON JR; CHANG K; FRANGOS M; HASAN KS; IDO Y; KAWAMURA T; NYENGAARD JR; VANDENENDEN M; KILO C; TILTON RG;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT PATHOL,BOX 8118,660 S EUCLID AVE ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT PEDIAT ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT INTERNAL MED ST LOUIS MO 63110 CHUBU ROSAI HOSP,DEPT INTERNAL MED NAGOYA JAPAN AARHUS UNIV,STEREOL RES LAB DK-8000 AARHUS DENMARK MIDDELHEIM HOSP,DEPT INTERNAL MED ANTWERP BELGIUM
Titolo Testata:
Diabetes
fascicolo: 6, volume: 42, anno: 1993,
pagine: 801 - 813
SICI:
0012-1797(1993)42:6<801:HPADC>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; ALDOSE REDUCTASE INHIBITOR; GLOMERULAR PROSTAGLANDIN PRODUCTION; INTRACELLULAR FREE CALCIUM; FREE-RADICAL GENERATION; NITRIC-OXIDE SYNTHASE; RETINAL BLOOD-FLOW; ENDOTHELIAL-CELLS; SUPEROXIDE ANION; 1,2-DIACYLGLYCEROL CONTENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
143
Recensione:
Indirizzi per estratti:
Citazione:
J.R. Williamson et al., "HYPERGLYCEMIC PSEUDOHYPOXIA AND DIABETIC COMPLICATIONS", Diabetes, 42(6), 1993, pp. 801-813

Abstract

Vasodilation and increased blood flow are characteristic early vascular responses to acute hyperglycemia and tissue hypoxia. In hypoxic tissues these vascular changes are linked to metabolic imbalances associated with impaired oxidation of NADH to NAD+ and the resulting increased ratio of NADH/NAD+. In hyperglycemic tissues these vascular changes also are linked to an increased ratio of NADH/NAD+, in this case because of an increased rate of reduction of NAD+ to NADH. Several lines ofevidence support the likelihood that the increased cytosolic ratio offree NADH/NAD+ caused by hyperglycemia, referred to as pseudohypoxia because tissue partial pressure oxygen is normal, is a characteristic feature of poorly controlled diabetes that mimics the effects of true hypoxia on vascular and neural function and plays an important role inthe pathogenesis of diabetic complications. These effects of hypoxia and hyperglycemia-induced pseudohypoxia on vascular and neural function are mediated by a branching cascade of imbalances in lipid metabolism, increased production of superoxide anion, and possibly increased nitric oxide formation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 12:43:07