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Titolo:
CYTOSKELETAL POLYPEPTIDES - CELL-TYPE-SPECIFIC MARKERS USEFUL IN INVESTIGATIVE OTORHINOLARYNGOLOGY
Autore:
BROEKAERT D;
Indirizzi:
STATE UNIV GHENT,FAC MED,PHYSIOL CHEM LAB,K L LEDEGANCKSTR 35 B-9000 GHENT BELGIUM
Titolo Testata:
International journal of pediatric otorhinolaryngology
fascicolo: 1, volume: 27, anno: 1993,
pagine: 1 - 20
SICI:
0165-5876(1993)27:1<1:CP-CMU>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERMEDIATE FILAMENT PROTEINS; MIDDLE-EAR CHOLESTEATOMAS; COCHLEAR HAIR-CELLS; ADULT HUMAN COCHLEA; INNER-EAR; OLFACTORY MUCOSA; ACTIN-FILAMENTS; EPIDERMAL TRANSGLUTAMINASE; NASOPHARYNGEAL CARCINOMA; CYTOKERATIN PROTEINS;
Keywords:
MICROFILAMENTS; MICROTUBULES; INTERMEDIATE FILAMENTS; ACTIN; ACTIN-BINDING PROTEINS; TUBULINE; MICROTUBULE-ASSOCIATED PROTEINS; CYTOKERATINS; VIMENTIN; NEUROFILAMENT POLYPEPTIDES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
75
Recensione:
Indirizzi per estratti:
Citazione:
D. Broekaert, "CYTOSKELETAL POLYPEPTIDES - CELL-TYPE-SPECIFIC MARKERS USEFUL IN INVESTIGATIVE OTORHINOLARYNGOLOGY", International journal of pediatric otorhinolaryngology, 27(1), 1993, pp. 1-20

Abstract

In the last decade, it has been established that eukaryotic cells possess a cytoskeleton, i.e. an integrated cytoplasmic network of microfilaments (MFs), microtubules (MTs) and intermediate filaments (IFs). Moreover, certain cell membrane specializations as well as the inner lamina of the nuclear membrane also participate in the cytoskeletal structure. Although this definition of the cytoskeleton is up to date it isobvious that the future course of cell biology will be reflected in arevised definition. While the bulk of structural polypeptides involved were characterized at regular intervals, surprisingly, the function of the cytoskeleton remained largely speculative and is still less precisely defined. The most widely postulated function concerns mechanical support and integration of diverse cellular activities and thus refers to cellular architecture. Briefly, the mechanical function is thought to involve cell movement, adhesive interaction with the extracellular matrix and neighbouring cells, as well as the stabilization of cellshape. The integrative function refers to intracellular movement, i.e. transport and positioning to the appropriate locations of organelles, intracellular particles, RNA and proteins. It has been established from numerous investigations that (certain) cytoskeletal polypeptides provide significant information about the cellular origin and differentiation state. This consideration constitutes the most prominent reflection underlying this review. Furthermore, this appreciation encouragesadditional efforts to explore these markers in normal and pathological conditions. The first purpose of this review is briefly to summarizeour present comprehension of the molecular components of the cytoskeleton, restricted to the filamentous trinity for practical reasons. Thesecond and main aim is to survey the field with respect to otorhinolaryngology-related issues. To the author's knowledge, this has not beendealt with in the past. In bridging this gap in the literature, I hope to provoke additional interest in one of the fastest moving areas ofcell biology. A comprehensive review covering the whole cytoskeleton has been covered by Preston et al. (The Cytoskeleton and Cell Motility. Blackie, Glasgow and London, 1990, pp. 7-69, 188-191). Additional information on the participating substructures is provided in the text, inclusive of last year's reviews.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 07:20:55