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Titolo:
RAPID EFFECTS OF DIETARY FISH-OIL ON PEROXISOMES IN MOUSE-LIVER
Autore:
DECRAEMER D; ROELS F; VANDENBRANDEN C;
Indirizzi:
VRIJE UNIV BRUSSELS,LAARBEEKLAAN 103 B-1090 BRUSSELS BELGIUM
Titolo Testata:
European journal of morphology
fascicolo: 1-2, volume: 31, anno: 1993,
pagine: 77 - 81
SICI:
0924-3860(1993)31:1-2<77:REODFO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-LIVER; BETA-OXIDATION; FATTY-ACIDS; CELLS; RETROCONVERSION; METABOLISM; 22-6(N-3);
Keywords:
CATALASE ACTIVITY; CATALASE CYTOCHEMISTRY; MORPHOMETRY; POLYUNSATURATED FATTY ACIDS; BETA-OXIDATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
D. Decraemer et al., "RAPID EFFECTS OF DIETARY FISH-OIL ON PEROXISOMES IN MOUSE-LIVER", European journal of morphology, 31(1-2), 1993, pp. 77-81

Abstract

We investigated hepatic catalase activity, and morphologic and morphometric alterations of hepatocellular peroxisomes after catalase cytochemistry, in mice given a diet supplemented with 10% Beromegan(R), a commercial fish oil preparation, for up to three days. Fish oil is rich in docosahexaenoic acid (C22:6 (n-3)) and in eicosapentaenoic acid (20:5 (n-3)). Hepatic catalase activity showed a gradual increase in micefed this diet, being significantly increased (136+/-10 U(B)/g liver) after three days when compared top controls (85+/-11 U(B)/g liver). Light microscopy indicated an increase in peroxisomal staining and peroxisomal proliferation. The latter observation was confirmed by ultrastructural morphometry: number, volume density and surface density of theperoxisomes were more than doubled after a three day diet containing fish oil. Peroxisomal size was not changed. These alterations are suggestive for an increased peroxisomal metabolism induced by a diet rich in poly-unsaturated fatty acids.

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Documento generato il 02/07/20 alle ore 22:15:09