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Titolo:
EVALUATION OF THE SAFETY AND EFFICACY OF A THYMIDINE KINASE, INVERTEDREPEAT, GI, AND GPX GENE-DELETED PSEUDORABIES VACCINE
Autore:
SWENSON SL; MCMILLEN J; HILL HT;
Indirizzi:
IOWA STATE UNIV SCI & TECHNOL,COLL VET MED,VET DIAGNOST LAB AMES IA 50011
Titolo Testata:
Journal of veterinary diagnostic investigation
fascicolo: 3, volume: 5, anno: 1993,
pagine: 341 - 346
SICI:
1040-6387(1993)5:3<341:EOTSAE>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
S.L. Swenson et al., "EVALUATION OF THE SAFETY AND EFFICACY OF A THYMIDINE KINASE, INVERTEDREPEAT, GI, AND GPX GENE-DELETED PSEUDORABIES VACCINE", Journal of veterinary diagnostic investigation, 5(3), 1993, pp. 341-346

Abstract

A thymidine kinase (TK), inverted repeat, glycoprotein I (gI) and glycoprotein X (gpX) gene-deleted modified live virus pseudorabies vaccine was evaluated for safety in swine and for efficacy in protecting swine against challenge with pseudorabies virus (PRV). Safety was evaluated by inoculating pregnant gilts intravenously and 3-day-old pigs intracerebrally with the vaccine. Efficacy was evaluated by 1) vaccinating3-day-old pigs with a minimal protective dose intranasally and then challenging with PRV 3 weeks postvaccination or 2) vaccinating weaned pigs with a standard field dose intramuscularly and then challenging with PRV 4 weeks postvaccination. The pigs vaccinated intranasally remained clinically normal following vaccination and challenge with PRV. The pigs vaccinated intramuscularly remained clinically normal followingvaccination, but mild respiratory sips were seen in some of the vaccinated pigs following challenge with PRV. Humoral immune response was evaluated with enzyme-linked immunosorbent assays (ELISAs) and a serum virus neutralization test. All of the intramuscularly vaccinated pigs became gI and gpX positive on differential ELISAs following challenge. All of the intranasally vaccinated pigs were seropositive on the indirect gI ELISA following challenge, but not all of the pigs were seropositive on the blocking gI ELISA or the gpX ELISA 3 weeks postchallenge.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 00:05:22