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Titolo:
THE INVOLVEMENT OF D(1) AND D(2) DOPAMINE-RECEPTORS IN AMPHETAMINE-INDUCED CHANGES IN STRIATAL UNIT-ACTIVITY IN BEHAVING RATS
Autore:
ROSAKENIG A; PUOTZ JK; REBEC GV;
Indirizzi:
INDIANA UNIV,DEPT PSYCHOL,PROGRAM NEURAL SCI BLOOMINGTON IN 47405 INDIANA UNIV,DEPT PSYCHOL,PROGRAM NEURAL SCI BLOOMINGTON IN 47405
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 619, anno: 1993,
pagine: 347 - 351
SICI:
0006-8993(1993)619:1-2<347:TIODAD>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREELY MOVING RATS; SUBSTITUTED BENZAMIDE; ANTIPSYCHOTIC-DRUGS; STIMULATION; NEURONS; D1-RECEPTOR; D2-RECEPTOR; STEREOTYPY; BMY-14802; SYSTEMS;
Keywords:
AMPHETAMINE; ETICLOPRIDE; SCH-23390; STRIATUM; SULPIRIDE; UNIT ACTIVITY;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
A. Rosakenig et al., "THE INVOLVEMENT OF D(1) AND D(2) DOPAMINE-RECEPTORS IN AMPHETAMINE-INDUCED CHANGES IN STRIATAL UNIT-ACTIVITY IN BEHAVING RATS", Brain research, 619(1-2), 1993, pp. 347-351

Abstract

Selective D1 (SCH-23390) and D2 (eticlopride and sulpiride) dopamine receptor antagonists were assessed for their ability to reverse the effects of 1.0 mg/kg D-amphetamine on excitatory motor-related neurons in the striatum of freely moving rats. SCH-23390 (0.125, 0.25, 0.5 and 1.0 mg/kg) rapidly and consistently blocked amphetamine-induced neuronal excitations as did eticlopride (0.25 and 1.0 mg/kg). In contrast, (-)-sulpiride (10, 20 and 40 mg/kg) failed to alter the neuronal response to amphetamine. Similarly, SCH-23390 and eticlopride also blocked the behavioral effects of amphetamine, but sulpiride did not. Collectively, these results support the involvement of D1 and D2 dopamine receptors in the excitatory effects of amphetamine on striatal neurons, butsuggest caution in assessing the neuronal and behavioral effects of sulpiride.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 17:36:54