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Titolo:
NGF IS RELEASED INTO PLASMA DURING HUMAN-PREGNANCY - AN OXYTOCIN-MEDIATED RESPONSE
Autore:
LUPPI P; LEVIMONTALCINI R; BRACCILAUDIERO L; BERTOLINI A; ARLETTI R; TAVERNARI D; VIGNETI E; ALOE L;
Indirizzi:
CNR,INST NEUROBIOL,VIALE C MARX 15 I-00156 ROME ITALY CNR,INST NEUROBIOL,VIALE C MARX 15 I-00156 ROME ITALY UNIV MODENA,INST PHARMACOL I-41100 MODENA ITALY HOSP MIRANDOLA,DEPT OBSTET & GYNAECOL I-41037 MIRANDOLA ITALY
Titolo Testata:
NeuroReport
fascicolo: 8, volume: 4, anno: 1993,
pagine: 1063 - 1065
SICI:
0959-4965(1993)4:8<1063:NIRIPD>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; MESSENGER-RNA; RAT; HYPOTHALAMUS; VASOPRESSIN; BEHAVIOR; PARTURITION; SECRETION; INCREASE; RECEPTOR;
Keywords:
LABOR; STRESS; LACTATION; NGF; OXYTOCIN; 2-SITE ENZYME IMMUNOASSAY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
P. Luppi et al., "NGF IS RELEASED INTO PLASMA DURING HUMAN-PREGNANCY - AN OXYTOCIN-MEDIATED RESPONSE", NeuroReport, 4(8), 1993, pp. 1063-1065

Abstract

THE presence of biologically active nerve growth factor (NGF) in the peripheral circulation of women during pregnancy, labour and lactationwas investigated. Using a sensitive immunoenzymatic assay (ELISA), wefound an approximately five-fold increase in plasma NGF levels duringlabour and lactation compared with the concentrations found at the term of gestation or in control healthy women. Since labour and lactation are characterized by activation of the hypothalamo-pituitary-adrenalaxis and by high plasma levels of the neurohypophyseal hormone oxytocin, and since the intravenous injection of oxytocin in female rats causes a 176% increase in the hypothalamic levels of NGF, it is possible that the increased amount of circulating NGF is correlated with one orboth of these events.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:52:30