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Titolo:
NATURAL CYCLE IN-VITRO FERTILIZATION-EMBRYO TRANSFER AT THE UNIVERSITY-OF-OTTAWA - AN INEFFICIENT THERAPY FOR TUBAL INFERTILITY
Autore:
CLAMAN P; DOMINGO M; GARNER P; LEADER A; SPENCE JEH;
Indirizzi:
737 PARKDALE AVE OTTAWA K1Y 4E9 ON CANADA UNIV OTTAWA,OTTAWA CIVIC HOSP,DEPT OBSTET & GYNECOL,GOAL PROGRAM OTTAWA K1N 6N5 ONTARIO CANADA
Titolo Testata:
Fertility and sterility
fascicolo: 2, volume: 60, anno: 1993,
pagine: 298 - 302
SICI:
0015-0282(1993)60:2<298:NCIFTA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
OVARIAN STIMULATION; OOCYTE RETRIEVAL; GONADOTROPIN;
Keywords:
IN-VITRO FERTILIZATION; EMBRYO TRANSFER; NATURAL CYCLE; UNSTIMULATED CYCLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
P. Claman et al., "NATURAL CYCLE IN-VITRO FERTILIZATION-EMBRYO TRANSFER AT THE UNIVERSITY-OF-OTTAWA - AN INEFFICIENT THERAPY FOR TUBAL INFERTILITY", Fertility and sterility, 60(2), 1993, pp. 298-302

Abstract

Objective: To describe our experience with natural cycle IVF making clinical and endocrine comparisons with our standard stimulated cycle IVF program. Design: We attempted 75 natural IVF-ET cycles with hCG given to preempt the LH surge and compared these with 450 attempts at standard superovulation IVF-ET done in our unit during the same time period. Patients: Natural cycle patients are normally ovulating women < age 38. Superovulation IVF-ET patients are all <41 years old. Patients in both groups had partners with normal semen parameters and tubal factor infertility. Main Outcome Measures: Cancellation rates, pregnancy rates per egg retrieval, per ET procedure, and luteal phase E2:P ratiosof the treatment cycles are compared. Results: There were 35 of 75 (47%) natural cycle and 112 of 450 (25%) superovulation cycle cancellations. An egg was retrieved in only 24 of 40 (60%) natural cycles and 336 of 338 (99%) superovulation egg retrieval procedures. Pregnancy rates per ovum pick-up procedure were significantly higher: 65 of 338 (19%) in the superovulation versus 2 of 40 (5%) in the natural cycle groups. Pregnancy rates per ET were not significantly different between natural IVF-ET, 2 of 18 (11%) and superovulation IVF-ET, 65 of 298 (22%). The E2:P ratios 5 days after ET were similar in both groups at 18 +/-4 after natural IVF-ET and 21 +/- 18 after superovulation IVF-ET. Conclusions: 1! Cancellation rates for natural cycle IVF are very high. 2! Midluteal E2:P ratios are the same in both groups. 3! Pregnancy rates per egg retrieval are significantly lower for natural versus superovulation IVF-ET. 4! In our experience, natural cycle IVF-ET is an inefficient therapy for tubal infertility compared with superovulation IVF-ET.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 19:38:38