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Titolo:
HP1.B, A HUMAN P-DOMAIN PEPTIDE HOMOLOGOUS WITH RAT INTESTINAL TREFOIL FACTOR, IS EXPRESSED ALSO IN THE ULCER-ASSOCIATED CELL LINEAGE AND THE UTERUS
Autore:
HAUSER F; POULSOM R; CHINERY R; ROGERS LA; HANBY AM; WRIGHT NA; HOFFMANN W;
Indirizzi:
MAX PLANCK INST PSYCHIAT,NEUROCHEM ABT D-82152 MARTINSRIED GERMANY MAX PLANCK INST PSYCHIAT,NEUROCHEM ABT D-82152 MARTINSRIED GERMANY ROYAL COLL SURGEONS ENGLAND,IMPERIAL CANC RES FUND,HISTOPATHOL UNIT LONDON WC2A 3PN ENGLAND
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 15, volume: 90, anno: 1993,
pagine: 6961 - 6965
SICI:
0027-8424(1993)90:15<6961:HAHPPH>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
PANCREATIC SPASMOLYTIC POLYPEPTIDE; HUMAN-BREAST-CANCER; EPIDERMAL GROWTH-FACTOR; AMINO-ACID-SEQUENCE; XENOPUS-LAEVIS SKIN; RESPONSIVE GENE PS2; MESSENGER-RNA; INTEGUMENTARY MUCIN; STOMACH MUCOSA; PROTEIN;
Keywords:
CROHN DISEASE; INFLAMMATORY BOWEL DISEASE; GROWTH FACTOR; HYPERPLASTIC POLYPS; SPASMOLYTIC POLYPEPTIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
F. Hauser et al., "HP1.B, A HUMAN P-DOMAIN PEPTIDE HOMOLOGOUS WITH RAT INTESTINAL TREFOIL FACTOR, IS EXPRESSED ALSO IN THE ULCER-ASSOCIATED CELL LINEAGE AND THE UTERUS", Proceedings of the National Academy of Sciences of the United Statesof America, 90(15), 1993, pp. 6961-6965

Abstract

The six-cysteine P-domain motif forms the basic repeat unit of a growing family of mucin-associated peptides. A precursor for a human secretory polypeptide has been discovered by molecular cloning and deduced to have a single P-domain, termed hP1.B. The pre-pro-peptide has 67% amino acid identity with rat intestinal trefoil factor. We find, using the techniques of RNA analysis and in situ hybridization, that this P-domain peptide is expressed in the human gastrointestinal tract, wherea number of pathological conditions affect its expression, and surprisingly find it is expressed in the uterus also. In the intestine, hP1.B is expressed by goblet cells, but in Crohn disease this peptide is synthesized and secreted additionally by the ulcer-associated cell lineage that is known to secrete two other trefoil peptides, pS2 and spasmolytic polypeptide (hSP). In the stomach, hP1.B mRNA is relatively scarce but is more abundant in foci of intestinal metaplasia and near to ulceration. Mucin-rich epithelial cells in hyperplastic polyps of the colon also express this peptide. The discovery-of this P-domain peptide and its expression in association with mucins support the hypothesisthat P-domains with mucins may subserve related functions in the maintenance and repair of mucosal function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 15:38:50