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Titolo:
EXPANDED POLYTETRAFLUOROETHYLENE ARTERIAL PROSTHESES IN HUMANS - HISTOPATHOLOGICAL STUDY OF 298 SURGICALLY EXCISED GRAFTS
Autore:
GUIDOIN R; CHAKFE N; MAUREL S; HOW T; BATT M; MAROIS M; GOSSELIN C;
Indirizzi:
UNIV LAVAL,DEPT SURG,EXPTL SURG LAB,ROOM 1701,SERV BLDG QUEBEC CITY G1K 7P4 QUEBEC CANADA UNIV LAVAL,DEPT PATHOL QUEBEC CITY G1K 7P4 QUEBEC CANADA ST FRANCOIS ASSISE,INST BIOMAT QUEBEC CITY PQ CANADA UNIV LIVERPOOL,DEPT CHEM ENGN LIVERPOOL L69 3BX ENGLAND CHU NICE,HOP ANNEXE REPUBL NICE FRANCE
Titolo Testata:
Biomaterials
fascicolo: 9, volume: 14, anno: 1993,
pagine: 678 - 693
SICI:
0142-9612(1993)14:9<678:EPAPIH>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR GRAFTS; FEMOROPOPLITEAL BYPASS; PTFE PROSTHESES; AUTOGENOUS VEIN; SAPHENOUS-VEIN; MICROPOROUS POLYTETRAFLUOROETHYLENE; SCANNING ELECTRON; ENDOTHELIAL-CELLS; HEALING-PROCESS; LIMB SALVAGE;
Keywords:
VASCULAR PROSTHESES; PTFE GRAFT; HEALING CHARACTERISTIC; EXPLANT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
64
Recensione:
Indirizzi per estratti:
Citazione:
R. Guidoin et al., "EXPANDED POLYTETRAFLUOROETHYLENE ARTERIAL PROSTHESES IN HUMANS - HISTOPATHOLOGICAL STUDY OF 298 SURGICALLY EXCISED GRAFTS", Biomaterials, 14(9), 1993, pp. 678-693

Abstract

The expanded polytetrafluoroethylene vascular prosthesis is considered to be the best synthetic alternative for peripheral arterial reconstruction. Most studies on the healing characteristics Of expanded polytetrafluoroethylene prostheses have been carried out on animals, and very few data are available on prostheses implanted in humans long term. We implanted 298 expanded polytetrafluoroethylene grafts as arterial substitutes in humans. The mean duration of implantation was 523 d andthe grafts were implanted mainly for infrainguinal or axillofemoral bypass. The cellular and collagen infiltration of the microporous expanded polytetrafluoroethylene structure was generally poor. Infiltrationoccurred mainly in the external region of the prosthetic wall and increased with the duration of implantation. The external reinforcement was not a major factor in limiting tissue infiltration. The luminal surfaces were covered with a thin, irregular layer of organized fibrin, interspersed with exposed expanded polytetrafluoroethylene areas. Mineral deposits were observed in five cases. Despite poor healing, the clinical performance of expanded polytetrafluoroethylene vascular prostheses is relatively good. Since the chief advantage of this material is good mechanical stability in vivo, any modifications of the graft to improve healing characteristics or thrombogenic properties should not be made at the expense of stability in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:17:12