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Titolo:
POLYUNSATURATED FATTY-ACIDS IN HEART-MUSCLE AND ALPHA(1)-ADRENOCEPTORBINDING-PROPERTIES
Autore:
SKULADOTTIR GV; SCHIOTH HB; GUDBJARNASON S;
Indirizzi:
UNIV ICELAND,INST SCI,DUNHAGA 3 IS-107 REYKJAVIK ICELAND
Titolo Testata:
Biochimica et biophysica acta
fascicolo: 1, volume: 1178, anno: 1993,
pagine: 49 - 54
SICI:
0006-3002(1993)1178:1<49:PFIHAA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADENYLATE-CYCLASE; MEMBRANE PHOSPHOLIPIDS; REVERSIBLE ALTERATIONS; ADRENERGIC-RECEPTORS; BETA-ADRENOCEPTORS; DESENSITIZATION; GLUCOCORTICOIDS; STIMULATION; CARDIOMYOCYTES; NOREPINEPHRINE;
Keywords:
PHOSPHOLIPID; FATTY ACID; ADRENOCEPTOR; EPINEPHRINE; HYDROCORTISONE; (HEART MUSCLE); (RAT);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
G.V. Skuladottir et al., "POLYUNSATURATED FATTY-ACIDS IN HEART-MUSCLE AND ALPHA(1)-ADRENOCEPTORBINDING-PROPERTIES", Biochimica et biophysica acta, 1178(1), 1993, pp. 49-54

Abstract

Modifications of membrane phospholipids and binding characteristics of adrenoceptors by hydrocortisone and epinephrine were examined in sarcolemmal preparation from rat heart muscle. The influence of hydrocortisone and epinephrine on the fatty acid composition of membrane phospholipids and the affinity (1/K(d)) and number of binding sites (B(max))of alpha1- and beta-adrenoceptors was studied in male Wistar rats treated daily for 7 days with the hormones. The alpha1- and beta-adrenoceptors were characterized by using the antagonist ligands H-3!prazosinand H-3!dihydroalprenolol, respectively. Administration of the horinones altered significantly the composition of fatty acids, decreased linoleic acid (18:2(n - 6)) level of both phosphatidylcholine and phosphatidylethanolamine, and increased arachidonic acid (20:4(n - 6)) level of phosphatidylcholine and docosahexaenoic acid (22:6(n - 3)) level in both phosphatidylcholine and phosphatidylethanolamine. The binding sites of alpha1-adrenoceptors were of high affinity in the control group. Following administration of the hormones K(d) of alpha1-adrenoceptors increased markedly. The number of alpha1-adrenoceptors binding sites did not change significantly due to the hormones. In contrast, while the hormone treatments did not alter the affinity of the beta-adrenoceptors the number of binding sites were significantly decreased by the hormones. The results indicate that the decrease in affinity of alpha1-adrenoceptors and the down-regulation of beta-adrenoceptors is accompanied by alteration in percentage fatty acid compositions of phosphatidylethanolamine and phosphatidylcholine in cardiac muscle.

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Documento generato il 11/07/20 alle ore 10:25:50