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Titolo:
ALTERED CA2-KINASE DEFICIENCIES( RESPONSES IN MUSCLES WITH COMBINED MITOCHONDRIAL AND CYTOSOLIC CREATINE)
Autore:
STEEGHS K; BENDERS A; OERLEMANS F; DEHAAN A; HEERSCHAP A; RUITENBEEK W; JOST C; VANDEURSEN J; PERRYMAN B; PETTE D; BRUCKWILDER M; KOUDIJS J; JAP P; VEERKAMP J; WIERINGA B;
Indirizzi:
UNIV NIJMEGEN,FAC MED SCI,DEPT CELL BIOL & HISTOL,POB 9101 NL-6500 HBNIJMEGEN NETHERLANDS UNIV NIJMEGEN,FAC MED SCI,DEPT CELL BIOL & HISTOL NL-6500 HB NIJMEGENNETHERLANDS UNIV NIJMEGEN,FAC MED SCI,DEPT BIOCHEM NL-6500 HB NIJMEGEN NETHERLANDS UNIV NIJMEGEN,FAC MED SCI,DEPT DIAGNOST RADIOL NL-6500 HB NIJMEGEN NETHERLANDS UNIV NIJMEGEN,FAC MED SCI,DEPT PEDIAT NL-6500 HB NIJMEGEN NETHERLANDS FREE UNIV AMSTERDAM,DEPT MUSCLE & EXERCISE PHYSIOL,FAC HUMAN MOVEMENTSCI NL-1081 BT AMSTERDAM NETHERLANDS UNIV COLORADO,HLTH SCI CTR,DIV CARDIOL DENVER CO 80262 UNIV KONSTANZ,DEPT BIOL D-7834 CONSTANCE GERMANY
Titolo Testata:
Cell
fascicolo: 1, volume: 89, anno: 1997,
pagine: 93 - 103
SICI:
0092-8674(1997)89:1<93:ACDRIM>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELLULAR-ENERGY METABOLISM; SKELETAL-MUSCLE; SARCOPLASMIC-RETICULUM; MICE; COMPARTMENTATION; PHOSPHORYLATION; HOMEOSTASIS; CONTRACTION; RELAXATION; PHOSPHATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
K. Steeghs et al., "ALTERED CA2-KINASE DEFICIENCIES( RESPONSES IN MUSCLES WITH COMBINED MITOCHONDRIAL AND CYTOSOLIC CREATINE)", Cell, 89(1), 1997, pp. 93-103

Abstract

We have blocked creatine kinase (CK)-mediated phosphocreatine (PCr) reversible arrow ATP transphosphorylation in skeletal muscle by combining targeted mutations in the genes encoding mitochondrial and cytosolic CK in mice. Contrary to expectation, the PCr level was only marginally affected, but the compound was rendered metabolically inert. Mutantmuscles in vivo showed significantly impaired tetanic force output, increased relaxation times, altered mitochondrial volume and location, and conspicuous tubular aggregates of sarcoplasmic reticulum membranes, as seen in myopathies with electrolyte disturbances. In depolarized myotubes cultured in vitro, CK absence influenced both the release andsequestration of Ca2+. Our data point to a direct link between the CK-PCr system and Ca2+-flux regulation during the excitation and relaxation phases of muscle contraction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:02:06