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Titolo:
THE EFFECT OF DELETERIOUS MUTATIONS ON NEUTRAL MOLECULAR VARIATION
Autore:
CHARLESWORTH B; MORGAN MT; CHARLESWORTH D;
Indirizzi:
UNIV CHICAGO,DEPT ECOL & EVOLUT CHICAGO IL 60637
Titolo Testata:
Genetics
fascicolo: 4, volume: 134, anno: 1993,
pagine: 1289 - 1303
SICI:
0016-6731(1993)134:4<1289:TEODMO>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACHAETE-SCUTE REGION; RESTRICTION-MAP VARIATION; DROSOPHILA-MELANOGASTER; NATURAL-POPULATIONS; DNA POLYMORPHISM; EVOLUTIONARY ADVANTAGE; INBREEDING DEPRESSION; NONEQUILIBRIUM MODELS; SELF-FERTILIZATION; CENTROMERIC REGION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
70
Recensione:
Indirizzi per estratti:
Citazione:
B. Charlesworth et al., "THE EFFECT OF DELETERIOUS MUTATIONS ON NEUTRAL MOLECULAR VARIATION", Genetics, 134(4), 1993, pp. 1289-1303

Abstract

Selection against deleterious alleles maintained by mutation may cause a reduction in the amount of genetic variability at linked neutral sites. This is because a new neutral variant can only remain in a largepopulation for a long period of time if it is maintained in gametes that are free of deleterious alleles, and hence are not destined for rapid elimination from the population by selection. Approximate formulasare derived for the reduction below classical neutral values resulting from such background selection against deleterious mutations, for the mean times to fixation and loss of new mutations, nucleotide site diversity, and number of segregating sites. These formulas apply to random-mating populations with no genetic recombination, and to populations reproducing exclusively asexually or by self-fertilization. For a given selection regime and mating system, the reduction is an exponential function of the total mutation rate to deleterious mutations for thesection of the genome involved. Simulations show that the effect decreases rapidly with increasing recombination frequency or rate of outcrossing. The mean time to loss of new neutral mutations and the total number of segregating neutral sites are less sensitive to background selection than the other statistics, unless the population size is of the order of a hundred thousand or more. The stationary distribution of allele frequencies at the neutral sites is correspondingly skewed in favor of rare alleles, compared with the classical neutral result. Observed reductions in molecular variation in low recombination genomic regions of sufficiently large size, for instance in the centromere-proximal regions of Drosophila autosomes or in highly selfing plant populations, may be partly due to background selection against deleterious mutations.

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Documento generato il 05/12/20 alle ore 22:25:28