Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
SKELETAL-MUSCLE SODIUM AND POTASSIUM CHANGES AFTER SUCCESSFUL SURGERYIN ACROMEGALY - RELATION TO BODY-COMPOSITION, BLOOD-GLUCOSE, PLASMA-INSULIN AND BLOOD-PRESSURE
Autore:
LANDIN K; PETRUSON B; JAKOBSSON KE; BENGTSSON BA;
Indirizzi:
GOTHENBURG UNIV,SAHLGRENS HOSP,DEPT MED 2 S-41345 GOTHENBURG SWEDEN GOTHENBURG UNIV,SAHLGRENS HOSP,DEPT NEUROSURG S-41345 GOTHENBURG SWEDEN GOTHENBURG UNIV,SAHLGRENS HOSP,DEPT OTORHINOLARYNGOL S-41345 GOTHENBURG SWEDEN
Titolo Testata:
Acta endocrinologica
fascicolo: 5, volume: 128, anno: 1993,
pagine: 418 - 422
SICI:
0001-5598(1993)128:5<418:SSAPCA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-HORMONE; HYPERTENSION; INTOLERANCE; SECRETION; WEIGHT; RATIO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
K. Landin et al., "SKELETAL-MUSCLE SODIUM AND POTASSIUM CHANGES AFTER SUCCESSFUL SURGERYIN ACROMEGALY - RELATION TO BODY-COMPOSITION, BLOOD-GLUCOSE, PLASMA-INSULIN AND BLOOD-PRESSURE", Acta endocrinologica, 128(5), 1993, pp. 418-422

Abstract

The aim of this study was to investigate the skeletal muscle sodium/potassium (Na/K) ratio in acromegaly before and 1 year after trans-sphenoidal removal of a growth hormone (GH)-secreting pituitary adenoma. Muscle biopsies were taken and skeletal muscle electrolytes, body composition, glucose, insulin and blood pressure were studied. Fasting blood glucose and plasma insulin levels, but not blood pressure, were higher in acromegatic patients (N = 9) than in controls (N = 6). The skeletal muscle potassium content was higher (p<0.01) but the sodium content and the Na/K ratio were lower (p<0.05 and p<0.001, respectively) in untreated patients with acromegaly as compared to weight-matched healthy controls. Elevated GH, glucose and insulin levels normalized after surgery. Blood pressure remained unchanged. The total body potassium content, the lean body mass and the total body water content decreased and the body fat content increased while the body weight was unchanged. The skeletal muscle potassium content decreased from median (range)! 9.8 (9.2-11.5) to 7.7 (5.7-9.5) mmol/100 g wet wt (p<0.001). The skeletal muscle sodium content increased from 2.8 (2.5-3.9) to 5.1 (4.3-6.7) mmol/100 g wet wt (p<0.001) and the Na/K ratio increased from 0.28(0.26-0.38) to 0.56 (0.51-1.18) (p<0.001) after surgery, which is a higher level than the controls with a Na/K ratio of 0.47 (0.39-0.84) (p<0.01). These changes seem to be mediated by a decreased GH effect on the Na/K pump after successful trans-sphenoidal surgery in acromegaly.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:06:38