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Titolo:
NEUTROPHIL RESPONSE TO NONTYPABLE HAEMOPHILUS-INFLUENZAE IN RESPIRATORY-INFECTIONS
Autore:
AHMED K; ICHINOSE A; DAI TC; TAKAHASHI A; UTSUNOMIYA Y; KAWAKAMI K; NAGATAKE T; MATSUMOTO K;
Indirizzi:
NAGASAKI UNIV,INST TROP MED,DEPT INTERNAL MED,1-12-4 SAKAMOTO NAGASAKI 852 JAPAN NAGASAKI UNIV,INST TROP MED,ELECTRON MICROSCOPE LAB NAGASAKI 852 JAPAN
Titolo Testata:
Microbiology and immunology
fascicolo: 9, volume: 37, anno: 1993,
pagine: 671 - 677
SICI:
0385-5600(1993)37:9<671:NRTNHI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMOPHILUS-INFLUENZAE; EPITHELIAL-CELLS; FIMBRIATION; ADHERENCE; INVITRO; TRACT; BLEBS;
Keywords:
SPUTUM; ELECTRON MICROSCOPY; NEUTROPHIL; HAEMOPHILUS-INFLUENZAE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
K. Ahmed et al., "NEUTROPHIL RESPONSE TO NONTYPABLE HAEMOPHILUS-INFLUENZAE IN RESPIRATORY-INFECTIONS", Microbiology and immunology, 37(9), 1993, pp. 671-677

Abstract

Sputa from patients with respiratory infections by nontypable Haemophilus influenzae (H. influenzae) were investigated by electron microscopy. The cell wall of H. influenzae appeared wavy and nonwavy. In the cell wall the peptidoglycan layer was ill-defined. These patients had adequate IgG response in the serum against H. influenzae. However neither capsule nor fimbriae were found. Different stages of phagocytosis and destruction of the bacteria by polymorphonuclear neutrophils (PMN) were observed. PMNs were also found to phagocytose the debris. Evidences were found that the debris is formed mainly by the destruction of polymorphonuclear neutrophil. Extracellular lysosomes were also observed, which may have a role in destruction of both bacteria and host tissue. It was concluded that nontypable H. influenzae are nonfimbriated and noncapsulated during infection. Debris are the end product of PMN destruction, and phagocytosis of debris by PMNs has a role in the pathogenesis of chronic respiratory diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/08/20 alle ore 20:00:04