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Titolo:
INVOLVEMENT OF SPINAL ADENOSINE A(1) AND A(2) RECEPTORS IN FENTANYL-INDUCED MUSCULAR RIGIDITY IN THE RAT
Autore:
LUI PW;
Indirizzi:
VET GEN HOSP,DEPT ANESTHESIOL,SHIH PAI RD,SECT 2 TAIPEI 11217 TAIWAN NATL YANG MING UNIV,SCH MED,DEPT ANESTHESIOL TAIPEI 112 TAIWAN
Titolo Testata:
Neuroscience letters
fascicolo: 3, volume: 224, anno: 1997,
pagine: 189 - 192
SICI:
0304-3940(1997)224:3<189:IOSAAA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUSCLE RIGIDITY; CORD; ANTINOCICEPTION; LOCALIZATION; CALCIUM; SITES;
Keywords:
ADENOSINE A(1) ANTAGONIST; 1-ALLYL-3,7-DIMETHYL-8-P-SULFOPHENYL-XANTHINE; ADENOSINE A(2) ANTAGONIST; 3,7-DIMETHYL-1-PROPARGYLXANTHANE; FENTANYL; MUSCULAR RIGIDITY; SPINAL CORD; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
P.W. Lui, "INVOLVEMENT OF SPINAL ADENOSINE A(1) AND A(2) RECEPTORS IN FENTANYL-INDUCED MUSCULAR RIGIDITY IN THE RAT", Neuroscience letters, 224(3), 1997, pp. 189-192

Abstract

In the present study, using hydrophilic adenosine antagonists either selective to A(1) or A(2) receptors, we investigated the central and spinal adenosinergic participation in fentanyl-induced muscular rigidity. Adult Sprague-Dawley rats were anesthetized with ketamine and were under mechanical ventilation. Fentanyl (100 mu g/kg, i.v.) consistently elicited electromyographic (EMG) activation in the sacrococcygeal dorsalis lateralis muscle. This implied muscular rigidity was not blocked by i.c.v. administration of the adenosine A(1) antagonist, 1-allyl-3,7-dimethyl-8-p-sulfophenyl-xanthine (ADSPX; 20 or 40 nmol/2.5 mu l), except at higher dose (80 nmol). Equimolar doses of the adenosine A(2)antagonist, 3,7-dimethyl-1-propargylxanthane (DMPX), did not exert any inhibitory effect on fentanyl-induced rigidity. Intrathecal (i.t) administration of the same doses of ADSPX (20, 40 or 80 nmol/10 mu l) appreciably suppressed the EMG activation. However, the rigidity was only inhibited by 40 or 80 nmol (i.t.) of DMPX, but not by the lowest dose. High-dose (80 nmol, i.t) adenosine A(1) or A(2) antagonist per se did not induce motor impairment or hindlimb paralysis in conscious animals. These results suggest that adenosine A(1) and A(2) receptors in the spinal cord may play a more crucial role than those in the central nervous system (CNS) in fentanyl-induced muscular rigidity in rats. (C) 1997 Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 21:25:38