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Titolo:
LONG-RANGE MAPPING OF MIS-2, A COMMON PROVIRUS INTEGRATION SITE IDENTIFIED IN MURINE LEUKEMIA VIRUS-INDUCED THYMOMAS AND LOCATED 160 KILOBASE PAIRS DOWNSTREAM OF MYB
Autore:
VILLENEUVE L; JIANG XY; TURMEL C; KOZAK CA; JOLICOUER P;
Indirizzi:
INST RECH CLIN MONTREAL,MOLEC BIOL LAB MONTREAL H2W 1R7 QUEBEC CANADA INST RECH CLIN MONTREAL,MOLEC BIOL LAB MONTREAL H2W 1R7 QUEBEC CANADA XEROX RES CTR CANADA LTD MISSISSAUGA L5K 2L1 ONTARIO CANADA NIAID,MOLEC MICROBIOL LAB BETHESDA MD 20892 UNIV MONTREAL,DEPT MICROBIOL & IMMUNOL MONTREAL H3C 3J7 QUEBEC CANADA MCGILL UNIV,DEPT EXPTL MED MONTREAL H3G 1A4 PQ CANADA
Titolo Testata:
Journal of virology
fascicolo: 10, volume: 67, anno: 1993,
pagine: 5733 - 5739
SICI:
0022-538X(1993)67:10<5733:LMOMAC>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL LYMPHOMAS; C-MYB; PLASMACYTOID LYMPHOSARCOMAS; DISEASE SPECIFICITY; NUCLEOTIDE-SEQUENCE; VIRAL INTEGRATION; RAT THYMOMAS; MOLONEY; MOUSE; DNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
L. Villeneuve et al., "LONG-RANGE MAPPING OF MIS-2, A COMMON PROVIRUS INTEGRATION SITE IDENTIFIED IN MURINE LEUKEMIA VIRUS-INDUCED THYMOMAS AND LOCATED 160 KILOBASE PAIRS DOWNSTREAM OF MYB", Journal of virology, 67(10), 1993, pp. 5733-5739

Abstract

The nondefective Moloney murine leukemia virus (MuLV) induces clonal or oligoclonal T-cell tumors in mice or rats. The proviruses of these nondefective MuLVs have been shown to act as insertion mutagens most frequently activating an adjacent cellular gene involved in cell growthcontrol. Mutations by provirus insertions, recognized as common provirus integration sites, have been instrumental in identifying novel cellular genes involved in tumor formation. We have searched for new common provirus integration sites in Moloney MuLV-induced thymomas. Using cellular sequences flanking a provirus cloned from one of these tumors, we found one region, designated Mis-2, which was the target of provirus integration in a low (3%) percentage of these tumors. Mis-2 was mapped on mouse chromosome 10, approximately 160 kbp downstream of myb. The Mis-2 region may contain a novel gene involved in tumor development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 19:43:39