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Titolo:
NEUROGLIAL CHOLINESTERASES IN THE NORMAL BRAIN AND IN ALZHEIMERS-DISEASE - RELATIONSHIP TO PLAQUES, TANGLES, AND PATTERNS OF SELECTIVE VULNERABILITY
Autore:
WRIGHT CI; GEULA C; MESULAM MM;
Indirizzi:
BETH ISRAEL HOSP,DEPT NEUROL,DIV NEUROSCI & BEHAV NEUROL,DENNY BROWN LABS,330 BROOKLINE AVE BOSTON MA 02215 BETH ISRAEL HOSP,DEPT NEUROL,DIV NEUROSCI & BEHAV NEUROL,DENNY BROWN LABS,330 BROOKLINE AVE BOSTON MA 02215 HARVARD UNIV,SCH MED BOSTON MA 02115
Titolo Testata:
Annals of neurology
fascicolo: 3, volume: 34, anno: 1993,
pagine: 373 - 384
SICI:
0364-5134(1993)34:3<373:NCITNB>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHONDROITIN SULFATE PROTEOGLYCAN; AMYLOID PROTEIN-PRECURSOR; TRYPSIN-LIKE ACTIVITY; NEUROFIBRILLARY TANGLES; MOLECULAR-FORMS; CEREBRAL-CORTEX; CEREBROSPINAL-FLUID; ELECTRIC-EEL; ACETYLCHOLINESTERASE; BUTYRYLCHOLINESTERASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
68
Recensione:
Indirizzi per estratti:
Citazione:
C.I. Wright et al., "NEUROGLIAL CHOLINESTERASES IN THE NORMAL BRAIN AND IN ALZHEIMERS-DISEASE - RELATIONSHIP TO PLAQUES, TANGLES, AND PATTERNS OF SELECTIVE VULNERABILITY", Annals of neurology, 34(3), 1993, pp. 373-384

Abstract

Butyrylcholinesterase (BChE) and an altered form of acetylcholinesterase (AChE) accumulate in the plaques and tangles of Alzheimer's disease (AD). The sources for these plaque- and tangle-bound cholinesteraseshave not been identified. We now report that AChE and BChE activitieswith pH preferences and inhibitor selectivities identical to those ofplaque- and tangle-bound cholinesterases are found in the astrocytes and oligodendrocytes of control and AD brains. These glial-type cholinesterases are selectively inhibited by indolamines and protease inhibitors. In control brains glial-type cholinesterases appear confined to the intracellular space, whereas in patients with AD they decorate plaques and tangles as well. In control and AD brains AChE-positive glia are distributed throughout the cortical layers and subcortical white matter, whereas BChE-positive glia reach high densities only in the deep cortical layers and white matter. In non-AD control brains, the ratio of BChE to AChE glia was higher in entorhinal and inferotemporal cortex, two regions with a high susceptibility to the pathology of AD, than in primary somatosensory and visual cortex, two areas with a relatively lower susceptibility to the disease process. There were no age-related differences in the density or distribution of cholinesterase-positive glia. In comparison with age-matched control specimens, AD brains had a significantly higher density of BChE glia and a lower density of AChE glia in entorhinal and inferotemporal regions but not in the primary somatosensory or visual areas. These results suggest that glia constitute a likely source for the cholinesterase activity of plaques and tangles and that a high ratio of BChE- to AChE-positive glia may play a permissive or causative role in the neuropathology of AD.

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Documento generato il 26/11/20 alle ore 20:18:05