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Titolo:
BLOCKADE OF CA-45(2-METHYL-D-ASPARTATE RECEPTOR-ION CHANNEL BY THE NON-PSYCHOACTIVE CANNABINOID HU-211() INFLUX THROUGH THE N)
Autore:
NADLER V; MECHOULAM R; SOKOLOVSKY M;
Indirizzi:
TEL AVIV UNIV,GEORGE S WISE FAC LIFE SCI,DEPT BIOCHEM,NEUROBIOCHEM LAB IL-69978 TEL AVIV ISRAEL TEL AVIV UNIV,GEORGE S WISE FAC LIFE SCI,DEPT BIOCHEM,NEUROBIOCHEM LAB IL-69978 TEL AVIV ISRAEL HEBREW UNIV JERUSALEM,FAC MED,BRETTLER MED RES CTR JERUSALEM ISRAEL
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 622, anno: 1993,
pagine: 79 - 85
SICI:
0006-8993(1993)622:1-2<79:BOCRCB>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; CENTRAL NERVOUS-SYSTEM; RAT-BRAIN; ANTICONVULSANT MK-801; HIPPOCAMPAL-NEURONS; )H-3>TCP BINDING; DEPENDENT BLOCK; NMDA-RECEPTORS; L-GLUTAMATE; GLYCINE;
Keywords:
NMDA; PHENCYCLIDINE-LIKE; POLYAMINE; GLUTAMATE; GLYCINE; CANNABINOID; CA-45(2+) INFLUX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
V. Nadler et al., "BLOCKADE OF CA-45(2-METHYL-D-ASPARTATE RECEPTOR-ION CHANNEL BY THE NON-PSYCHOACTIVE CANNABINOID HU-211() INFLUX THROUGH THE N)", Brain research, 622(1-2), 1993, pp. 79-85

Abstract

The effects of the synthetic non-psychoactive cannabinoid (+)-(3S,4S)-7-hydroxy-DELTA6-tetrahydrocannabinoL 1,1-dimethylheptyl (HU-211) on the activity of the N-methyl-D-aspartate (NMDA) receptor/ion channel were examined. HU-211 non-competitively blocks the increase in binding of [H-3]N-[1-(2-thienyl)-cyclohexyl]piperidine ([H-3]TCP) induced by the polyamines spermine and spermidine or by glutamate and glycine. HU-211 does not, however, affect the direct binding of [H-3]glycine and [H-3]glutamate to their binding sites on the NMDA receptor, which suggests that the effects of HU-211 are not mediated via the binding sites of glutamate-, glycine- and phencyclidine-like drugs or of polyamines. HU-211 can also block Ca-45(2+) uptake through the NMDA-receptor/ion channel in primary cell cultures of rat forebrain. All of the above inhibitory effects of HU-211 on the NMDA-receptor/ion channel activity are stereospecific, since the (-)(3R,4R) enantiomer (HU-210) is ineffective.

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Documento generato il 22/10/20 alle ore 03:22:42