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Titolo:
DIETHYLGLYOXAL BIS(GUANYLHYDRAZONE), A POTENT INHIBITOR OF MAMMALIAN S-ADENOSYLMETHIONINE DECARBOXYLASE - EFFECTS ON CELL-PROLIFERATION ANDPOLYAMINE METABOLISM IN L1210-LEUKEMIA CELLS
Autore:
SVENSSON F; KOCKUM I; PERSSON L;
Indirizzi:
LUND UNIV,DEPT PHYSIOL,SOLVEGATAN 19 S-22362 LUND SWEDEN LUND UNIV,DEPT PHYSIOL,SOLVEGATAN 19 S-22362 LUND SWEDEN LUND UNIV,DEPT PHYSIOL & BIOPHYS S-22362 LUND SWEDEN
Titolo Testata:
Molecular and cellular biochemistry
fascicolo: 2, volume: 124, anno: 1993,
pagine: 141 - 147
SICI:
0300-8177(1993)124:2<141:DBAPIO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL GLYOXAL BIS(GUANYLHYDRAZONE); L-METHIONINE DECARBOXYLASE; ORNITHINE DECARBOXYLASE; IRREVERSIBLE INHIBITION; CULTURE; GROWTH;
Keywords:
DIETHYLGLYOXAL BIS(GUANYLHYDRAZONE); S-ADENOSYLMETHIONINE DECARBOXYLASE; POLYAMINES; L1210-CELLS; ANTIPROLIFERATIVE EFFECT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
F. Svensson et al., "DIETHYLGLYOXAL BIS(GUANYLHYDRAZONE), A POTENT INHIBITOR OF MAMMALIAN S-ADENOSYLMETHIONINE DECARBOXYLASE - EFFECTS ON CELL-PROLIFERATION ANDPOLYAMINE METABOLISM IN L1210-LEUKEMIA CELLS", Molecular and cellular biochemistry, 124(2), 1993, pp. 141-147

Abstract

The polyamines are cell constituents essential for growth and differentiation. S-Adenosylmethionine decarboxylase (AdoMetDC) catalyzes a key step in the polyamine biosynthetic pathway. Methylglyoxal bis(guanylhydrazone) (MGBG) is an anti-leukemic agent with a strong inhibitory effect against AdoMetDC. However, the lack of specificity limits the usefulness of MGBG. In the present report we have used an analog of MGBG, diethylglyoxal bis(guanylhydrazone) (DEGBG), with a much greater specificity and potency against AdoMetDC, to investigate the effects of AdoMetDC inhibition on cell proliferation and polyamine metabolism in mouse L1210 leukemia cells. DEGBG was shown to effectively inhibit AdoMetDC activity in exponentially growing L1210 cells. The inhibition of AdoMetDC was reflected in a marked decrease in the cellular concentrations of spermidine and spermine. The concentration of putrescine, on the other hand, was greatly increased. Treatment with DEGBG resulted ina compensatory increase in the synthesis of AdoMetDC demonstrating anefficient feedback control. Cells seeded in the presence of DEGBG ceased to grow after a lag period of 1-2 days, indicating that the cells contained an excess of polyamines which were sufficient for one or twocell cycles in the absence of polyamine synthesis. The present results indicate that analogs of MGBG, having a greater specificity against AdoMetDC, might be valuable for studies concerning polyamines and cellproliferation.

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Documento generato il 25/11/20 alle ore 18:55:36