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Titolo:
ROLE OF TRABECULAR MORPHOLOGY IN THE ETIOLOGY OF AGE-RELATED VERTEBRAL FRACTURES
Autore:
SNYDER BD; PIAZZA S; EDWARDS WT; HAYES WC; SCHAFFLER; ROSS;
Indirizzi:
BETH ISRAEL HOSP,CHARLES A DANA RES INST,ORTHOPAED BIOMECH LAB,330 BROOKLINE AVE BOSTON MA 02215 SUNY,HLTH SCI CTR,ORTHOPAED RES LAB SYRACUSE NY 13210 BETH ISRAEL HOSP,CHARLES A DANA RES INST,ORTHOPAED BIOMECH LAB,330 BROOKLINE AVE BOSTON MA 02215
Titolo Testata:
Calcified tissue international
, volume: 53, anno: 1993, supplemento:, 1
pagine: 190000014 - 190000022
SICI:
0171-967X(1993)53:<190000014:ROTMIT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUANTITATIVE COMPUTED-TOMOGRAPHY; BONE-MINERAL CONTENT; COMPRESSIVE STRENGTH; LUMBAR VERTEBRAE; NORMAL INDIVIDUALS; CELLULAR MECHANISMS; ASH DENSITY; SPONGY BONE; PREDICTION; VOLUME;
Keywords:
STEREOLOGY; MORPHOLOGY; OSTEOPOROSIS; VERTEBRAL BODY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
B.D. Snyder et al., "ROLE OF TRABECULAR MORPHOLOGY IN THE ETIOLOGY OF AGE-RELATED VERTEBRAL FRACTURES", Calcified tissue international, 53, 1993, pp. 190000014-190000022

Abstract

Osteoporotic compression fractures of the spine differ from most other age-related fractures in that they usually are associated with minimal trauma and with loads no greater than those encountered during normal activities of daily living. With aging and osteoporosis, there is progressive resorption of bone, resulting in reductions in bone density, thinning of trabeculae, and loss of trabecular contiguity. These changes in trabecular bone structure are associated with losses in bone strength which are disproportionate to the reductions in bone mass alone. To explain this disproportionate loss of bone strength, the prevailing opinion is that density reductions in the vertebral centrum are accompanied by a reduction in the number of trabeculae, by preferential resorption of horizontal trabeculae, and by hypertrophy of the remaining vertical trabeculae. To evaluate this view of vertebral morphology,we performed three-dimensional stereological analysis of trabecular bone extracted from midsagittal sections of first lumbar vertebral bodies from 12 donors spanning an age of 27-81 years. We found that both the number (R2 = 0.63, P < 0.01) and thickness (R2 = 0.91, p < 0.01) oftrabeculae decreased linearly with density (as expressed by bone volume fraction) whereas the spacing between the trabeculae (R2 = 0.61, P < 0.01) increased reciprocally. There were more vertical trabeculae with transverse trabeculae at all densities, and the number of vertical trabeculae changed with density at twice the rate of the number of transverse trabeculae (P < 0.001). These data do not support the prevailing view that there is preferential resorption of horizontal trabeculaeor hypertrophy of the remaining vertical trabeculae. Bone density wasalso a strong (R2 = 0.90, p < 0.01) power law function of the ratio of trabecular thickness to mean intertrabecular spacing. From buckling theory, the critical buckling load of a trabecula is related to this ratio of trabecular thickness to effective length. The changes in trabecular morphology observed with decreasing bone density thus pose a ''triple threat'' to the strength and stability of vertebral trabecular bone, as not only are there fewer trabeculae, but the remaining trabeculae are both thinner and longer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 15:17:23