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Titolo:
COMPLEXUS ADHAERENTES, A NEW GROUP OF DESMOPLAKIN-CONTAINING JUNCTIONS IN ENDOTHELIAL-CELLS - THE SYNDESMOS CONNECTING RETOTHELIAL CELLS OFLYMPH-NODES
Autore:
SCHMELZ M; FRANKE WW;
Indirizzi:
GERMAN CANC RES CTR,DIV CELL BIOL,NEUENHEIMER FELD 280 D-69120 HEIDELBERG GERMANY GERMAN CANC RES CTR,DIV CELL BIOL,NEUENHEIMER FELD 280 D-69120 HEIDELBERG GERMANY
Titolo Testata:
European journal of cell biology
fascicolo: 2, volume: 61, anno: 1993,
pagine: 274 - 289
SICI:
0171-9335(1993)61:2<274:CAANGO>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID-SEQUENCE; CONSTITUTIVE TRANSMEMBRANE GLYCOPROTEIN; DESMOSOMAL PLAQUE PROTEINS; NON-EPIDERMAL DESMOSOMES; ADHESION MOLECULES; CADHERIN FAMILY; EPITHELIAL-CELLS; STRESS FIBERS; MR-165000 DESMOGLEIN; TIGHT JUNCTIONS;
Keywords:
ADHERING JUNCTIONS; DESMOSOMES; CADHERINS; ENDOTHELIUM; LYMPH NODE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
96
Recensione:
Indirizzi per estratti:
Citazione:
M. Schmelz e W.W. Franke, "COMPLEXUS ADHAERENTES, A NEW GROUP OF DESMOPLAKIN-CONTAINING JUNCTIONS IN ENDOTHELIAL-CELLS - THE SYNDESMOS CONNECTING RETOTHELIAL CELLS OFLYMPH-NODES", European journal of cell biology, 61(2), 1993, pp. 274-289

Abstract

We describe, in bovine and human tissues, a new kind of adhering junctions (''complexus adhaerens'') which occur in certain vascular endothelia and, by morphological and compositional criteria, are neither desmosomes nor adhering junctions of the zonula (fascia) adhaerens category. A particularly abundant and complex subtype among the ''complexus adhaerens'' junctions is characteristic of the endothelium-related, stellate cells that form the three-dimensional filter meshwork of lymph node sinus. These ''retothelial'' cells are multiply interconnected byjunctions which are highly. polymorphic in shape and size, often showinterruptions and branches and can be traced for several micrometers. Their dense cytoplasmic plaque contains plakoglobin and desmoplakin but is practically negative for vinculin and alpha-actinin. In contrastto true desmosomes, including those of the dendritic reticulum cells of lymph node follicles, the retothelial junctions are negative for any of the known desmosomal cadherins (desmogleins and desmocollins) andalso for E- and M-cadherin. These cells, however, are rich in cadherin-5 which colocalizes with desmoplakin and plakoglobin in numerous, though not all sites, indicating that here cadherin-5 may contribute to the formation of a desmoplakin plaque. The complex arrangement of the retothelial form of complexus adhaerens, for which the term ''syndesmos'' is proposed, has been reconstructed from electron micrographs by acomputer-aided design. We also report that desmoplakin-positive complexus adhaerens junctions constitutively occur in various lymphatic endothelia of many other tissues, most prominently in submucosal lymph vessels, and discuss the possible function of this kind of junctions as a means to fortify cell connections between the tenuous endothelial cells and, in the lymph node sinus, to support their filtering functions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 05:36:39