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Titolo:
SHORT-CIRCUIT CURRENT RESPONSES TO 5-HYDROXYTRYPTAMINE IN HUMAN ILEALMUCOSA ARE MEDIATED BY A 5-HT(4) RECEPTOR
Autore:
BURLEIGH DE; BORMAN RA;
Indirizzi:
QUEEN MARY & WESTFIELD COLL,DEPT PHARMACOL,MILE END RD LONDON E1 4NS ENGLAND
Titolo Testata:
European journal of pharmacology
fascicolo: 1, volume: 241, anno: 1993,
pagine: 125 - 128
SICI:
0014-2999(1993)241:1<125:SCRT5I>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG ILEUM; INVOLVEMENT; TRANSPORT; COLON;
Keywords:
5-HT (5-HYDROXYTRYPTAMINE, SEROTONIN); MUCOSA; ION TRANSPORT; ILEUM; (HUMAN);
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
D.E. Burleigh e R.A. Borman, "SHORT-CIRCUIT CURRENT RESPONSES TO 5-HYDROXYTRYPTAMINE IN HUMAN ILEALMUCOSA ARE MEDIATED BY A 5-HT(4) RECEPTOR", European journal of pharmacology, 241(1), 1993, pp. 125-128

Abstract

5-Hydroxytryptamine (5-HT) increases short-circuit current when addedto the serosal side of human isolated ileal mucosa; mucosally applied5-HT was ineffective. Tetrodotoxin reduced both basal short-circuit current and increases in short-circuit current due to electrical field stimulation of mucosal nerves. However, neither tetrodotoxin, ondansetron nor methysergide plus ketanserin affected 5-HT induced increases in short-circuit current. Application of SDZ 205-557 (2-diethylaminoethyl-(2-methoxy-4-amino-5-chloro) benzoate) to the tissue caused a significant increase in the concentration ratio between two successive 5-HTresponse curves. It is concluded that the effect of 5-HT on short-circuit current of human ileal mucosa appears to be due to stimulation ofa 5-HT4 receptor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 14:07:56