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Titolo:
EFFECTS OF ANTIPSYCHOTIC-DRUGS ON LATENT INHIBITION - SENSITIVITY ANDSPECIFICITY OF AN ANIMAL BEHAVIORAL-MODEL OF CLINICAL DRUG-ACTION
Autore:
DUNN LA; ATWATER GE; KILTS CD;
Indirizzi:
DUKE UNIV,MED CTR,DEPT PSYCHIAT,BOX 3400 DURHAM NC 27710 EMORY UNIV,SCH MED,DEPT PSYCHIAT ATLANTA GA 30322 VET ADM MED CTR,PSYCHIAT SERV DURHAM NC 27705
Titolo Testata:
Psychopharmacology
fascicolo: 2-3, volume: 112, anno: 1993,
pagine: 315 - 323
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCHIZOPHRENIC ATTENTION DISORDER; CHRONIC AMPHETAMINE; HALOPERIDOL; BOOTSTRAP; CLOZAPINE; DOPAMINE; RATS; DISTRACTIBILITY; NEUROLEPTICS; PERFORMANCE;
Keywords:
ANIMAL MODEL; RAT; ANTIPSYCHOTIC; SCHIZOPHRENIA; LATENT INHIBITION; ATTENTION; SELECTIVE ATTENTION; CONDITIONED EMOTIONAL RESPONSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
60
Recensione:
Indirizzi per estratti:
Citazione:
L.A. Dunn et al., "EFFECTS OF ANTIPSYCHOTIC-DRUGS ON LATENT INHIBITION - SENSITIVITY ANDSPECIFICITY OF AN ANIMAL BEHAVIORAL-MODEL OF CLINICAL DRUG-ACTION", Psychopharmacology, 112(2-3), 1993, pp. 315-323

Abstract

Latent inhibition (LI) of a conditioned emotional response (CER) has been proposed as a quantitative measure of selective attention. We have assessed the parallels of the pharmacology of LI in rats with the clinical pharmacology of schizophrenia. Drug and vehicle treated rats were divided into groups and preexposed 20 times to cage illumination asa CS, or not preexposed. All groups were conditioned with 2 CS-footshock pairings. The following day CER, as measured by interruption of drinking in response to CS presentation, was recorded. LI was observed as a decreased CER in preexposed relative to non-preexposed animals. LIwas enhanced by haloperidol 0.3 mg/kg after 7 or 14 daily treatments,but not after a single acute dose. Haloperidol doses of 0.3 and 0.03 mg/kg enhanced LI, while doses of 0.003 and 3.0 mg/kg had no effect. Haloperidol enhancement of LI was unaffected by the coadministration ofthe anticholinergic agent trihexyphenidyl. Enhancement of LI is exhibited by the antipsychotic drugs fluphenazine, chlorpromazine, thiothixene, thioridazine, mesoridazine, and metoclopramide but not clozapine. The non-antipsychotic drugs pentobarbital, imipramine, chlordiazepoxide, trihexyphenidyl, and promethazine failed to enhance LI. LI exhibits striking parallels to the clinical pharmacology of schizophrenia.

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Documento generato il 09/04/20 alle ore 08:16:35