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Titolo:
PEROXYNITRITE MODIFICATION OF LOW-DENSITY-LIPOPROTEIN LEADS TO RECOGNITION BY THE MACROPHAGE SCAVENGER RECEPTOR
Autore:
GRAHAM A; HOGG N; KALYANARAMAN B; OLEARY V; DARLEYUSMAR V; MONCADA S;
Indirizzi:
WELLCOME RES LABS,LANGLEY COURT,S EDEN PK RD BECKENHAM BR3 3BS KENT ENGLAND WELLCOME RES LABS,LANGLEY COURT,S EDEN PK RD BECKENHAM BR3 3BS KENT ENGLAND MED COLL WISCONSIN,BIOPHYS RES INST MILWAUKEE WI 53226
Titolo Testata:
FEBS letters
fascicolo: 2, volume: 330, anno: 1993,
pagine: 181 - 185
SICI:
0014-5793(1993)330:2<181:PMOLLT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL-CELL MODIFICATION; HUMAN MONOCYTE-MACROPHAGES; NITRIC-OXIDE; OXIDATIVE MODIFICATION; CHOLESTEROL DEPOSITION; PLASMA-LIPOPROTEINS; LIPID-PEROXIDATION; MEDIATED OXIDATION; FOAM CELLS; SUPEROXIDE;
Keywords:
MACROPHAGE; PEROXYNITRITE; LOW-DENSITY LIPOPROTEIN; ATHEROSCLEROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
A. Graham et al., "PEROXYNITRITE MODIFICATION OF LOW-DENSITY-LIPOPROTEIN LEADS TO RECOGNITION BY THE MACROPHAGE SCAVENGER RECEPTOR", FEBS letters, 330(2), 1993, pp. 181-185

Abstract

Peroxynitrite is an oxidant which could be formed in the vasculature by the reaction of superoxide with nitric oxide. It is capable of modifying amino acid residues and of initiating lipid peroxidation. In thepresent study we have shown that peroxynitrite converts low density lipoprotein to a form recognized by the macrophage scavenger receptor and that this process is associated with modification of the protein and lipid, and with the oxidation of alpha-tocopherol to alpha-tocopherol quinone.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/02/20 alle ore 02:15:43